| 九例脑膜瘤细胞遗传学研究 |
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| 引用本文： | 季明芳,方思鸣,唐秉航. 九例脑膜瘤细胞遗传学研究[J]. 中华医学遗传学杂志, 1995, 0(6) |
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| 作者姓名： | 季明芳 方思鸣 唐秉航 |
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| 作者单位： | 广东省中山市肿瘤研究所，同济医科大学生物教研室，广东省中山市人民医院ＣＴ室 |
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| 摘 要： | 采用短期培养法对９例脑膜瘤组织进行细胞遗传学分析，７例获得成功。其中４例干系核型正常，３例干系为２２单体并伴有其它染色体异常，且双微体出现率较高，１例标记染色体发现罕见的均染区。其它常累及的染色体有１、４、１７、１９和２１号。本组染色体分析显示，２２号单体为脑膜瘤最恒定的染色体异常，其缺失与脑膜瘤病因学相关。
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| 关 键 词： | 脑膜瘤，染色体异常，短期培养法 |
CYTOGENETIC STUDIES OF NINE MENINGIOMAS |
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| Ji Mingfang,Fang Shiming,Tang Binghang. CYTOGENETIC STUDIES OF NINE MENINGIOMAS[J]. Chinese journal of medical genetics, 1995, 0(6) |
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| Authors: | Ji Mingfang Fang Shiming Tang Binghang |
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| Abstract: | Cytogenetic analysis of 9 cases of meningiomas were performed after short term tumor cell culture.Metaphase cells of 7 cases were arrested.Normal karyotype was found in 4 cases.Monosomy 22 in the remaining three cases with other chromosomal abnormalities included double minutes and homogeneously stainging region.Other chromosomes commonly involved were 1,4,17,19,and 21.Karyotypic analysis confirmed that monosomy 22 is the most consistent chromosomal abnormality in meningiomas.The results suggest that specific loss of region on chromosome 22 be associated with meningiomas oncogenesis. |
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| Keywords: | Meningiomas Chromosomal aberration Short term culture |
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