| 氨氯地平联合替米沙坦或复方阿米洛利的疗效及安全性比较 |
| |
| 引用本文： | 舒瑛,张艳梅,陈复琼,唐家荣,汪道文. 氨氯地平联合替米沙坦或复方阿米洛利的疗效及安全性比较[J]. 药物流行病学杂志, 2011, 0(6): 275-278 |
| |
| 作者姓名： | 舒瑛 张艳梅 陈复琼 唐家荣 汪道文 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院心内科（武汉 430030）;华中科技大学同济医学院附属同济医院心内科（武汉 430030）;华中科技大学同济医学院附属同济医院心内科（武汉 430030）;华中科技大学同济医学院附属同济医院心内科（武汉 430030）;华中科技大学同济医学院附属同济医院心内科（武汉 430030） |
| |
| 基金项目： | 湖北省卫生厅科研基金重点项目（编号：JX3A07） |
| |
| 摘 要： | 目的:比较氨氯地平联合替米沙坦和氨氯地平联合复方阿米洛利对轻中度原发性高血压患者的降压疗效和不良反应。方法:选择96例轻、中度原发性高血压患者,按随机及平行对照原则分为氨氯地平/复方阿米洛利组(A组)48例和氨氯地平/替米沙坦组(B组)48例,分别观察两组降压疗效,血生化指标影响及不良反应。观察时间12个月。结果:两组用药后收缩压和舒张压均有显著下降,组间比较差异无统计学意义(P>0.05)。两组治疗前后肝、肾功能及血糖等指标均无变化。A组治疗6月时血钾无变化,12月时血钾升高,6月和12月时尿酸均较入组时明显升高(P<0.05);B组治疗6月和12月时血钾及尿酸较入组时均无明显变化。B组不良反应发生率明显低于A组(P<0.05)。结论:氨氯地平联合替米沙坦与氨氯地平联合复方阿米洛利均有显著的降压效果。氨氯地平联合复方阿米洛利组不良反应发生率明显高于氨氯地平联合替米沙坦组。氨氯地平联合替米沙坦是更优化的联合治疗方案。
|
| 关 键 词： | 苯磺酸氨氯地平 替米沙坦 复方阿米洛利 原发性高血压 联合治疗 |
| 收稿时间： | 2011-02-18 |
| 修稿时间： | 2011-03-31 |
Comparison of Efficacy and Safety of Amlodipine Besylate Combined with Telmisartan and Amlodipine Besylate Amiloride Compound in Patients with Essential Hypertension |
| |
| Shu Ying,Zhang Yanmei,Chen Fuqiong,Tang Jiarong and Wang Daowen. Comparison of Efficacy and Safety of Amlodipine Besylate Combined with Telmisartan and Amlodipine Besylate Amiloride Compound in Patients with Essential Hypertension[J]. Chinese Journal of Pharmacoepidemiology, 2011, 0(6): 275-278 |
| |
| Authors: | Shu Ying Zhang Yanmei Chen Fuqiong Tang Jiarong Wang Daowen |
| |
| Affiliation: | Shu Ying,Zhang Yanmei,Chen Fuqiong,Tang Jiarong,Wang Daowen Department of Heart Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
| |
| Abstract: | Objective:To evaluate the efficacy and safety of amlodipine besylate combined with telmisartan and amlodipine besylate combined with amiloride compound in patients with mild and moderate essential hypertension.Method: 96 patients with essential hypertension were randomly divided into two groups.Group A(n=48)was given amlodipine besylate and amiloride compound and Group B(n=48)was administrated with amlodipine besylate and telmisartan.After the administration their blood pressure and heart rates were followe... |
| |
| Keywords: | Amlodipine besylate Telmisartan Amiloride compound Essential hypertension Combination therapy |
| 本文献已被 CNKI 维普 等数据库收录！ |
