| Glut1与Ki-67在结直肠癌中的表达及其与18F-FDG PET/CT SUVmax的相关性 |
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| 引用本文： | 李迎辞,于丽娟,田墨涵,王大龙,王文志. Glut1与Ki-67在结直肠癌中的表达及其与18F-FDG PET/CT SUVmax的相关性[J]. 中国医学影像技术, 2011, 27(9): 1855-1858 |
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| 作者姓名： | 李迎辞 于丽娟 田墨涵 王大龙 王文志 |
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| 作者单位： | 哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨,150081 |
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| 基金项目： | 黑龙江省自然科学基金(D200863)。 |
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| 摘 要： | 目的 探讨葡萄糖转运蛋白1(Glut1)与细胞增殖抗原标记物Ki-67在结直肠癌(CRC)中的表达及其与18F-FDG PET/CT显像最大标准摄取值(SUVmax)的关系。 方法 对33例经术后病理证实的CRC患者术前进行全身PET/CT检查,记录病灶的SUVmax,用免疫组化方法分析Glut1、Ki-67表达,并与SUVmax进行对比分析。 结果 Glut1和Ki-67在CRC中的表达均高于正常组织(t=－4.22、－3.04,P均<0.05)。Glut1在CRC中的阳性表达率显著高于正常组织(χ2=18.94,P<0.05),在低分化CRC中的阳性表达率(5/7,71.42%)高于中-低分化(1/3,33.33%)和中分化(16/23,69.57%)CRC。CRC的 SUVmax与Glut1的表达存在相关性(r=0.63,P<0.05),与Ki-67无相关性(r=0.24,P=0.36)。不同分化程度CRC的SUVmax之间差异无统计学意义(F=0.54,P=0.59);不同肉眼大体分型CRC的 SUVmax之间差异无统计学意义(t=－0.07, P=0.95)。 结论 Ki-67可反映CRC细胞的增殖状态;CRC的SUVmax可反映CRC组织中Glut1的表达水平。
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| 关 键 词： | 结直肠肿瘤 18F 氟脱氧葡萄糖 正电子发射型体层摄影术 体层摄影术,X线计算机 Glut1 Ki-67 |
| 收稿时间： | 2011-02-10 |
| 修稿时间： | 2011-03-26 |
Expression of Glut1 and Ki-67 of colorectal cancer and its correlation with SUVmax in 18F-FDG PET/CT |
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| LI Ying-ci,YU Li-juan,TIAN Mo-han,WANG Da-long and WANG Wen-zhi. Expression of Glut1 and Ki-67 of colorectal cancer and its correlation with SUVmax in 18F-FDG PET/CT[J]. Chinese Journal of Medical Imaging Technology, 2011, 27(9): 1855-1858 |
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| Authors: | LI Ying-ci YU Li-juan TIAN Mo-han WANG Da-long WANG Wen-zhi |
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| Affiliation: | Central of PET/CT, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Central of PET/CT, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Central of PET/CT, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Central of PET/CT, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Central of PET/CT, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China |
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| Abstract: | Objective To explore the expression of glucose transporter 1(Glut1) and Ki-67 of colorectal cancer(CRC) and it's correlation with maximum standard uptake value(SUVmax) in 18F-FDG PET/CT.Methods Thirty-three patients with CRC proved by postoperative pathology underwent PET/CT imaging preoperatively,and SUVmax of lesions were recorded.The expression of Glut1 and Ki-67 were analyzed by immunohistochemistry,and compared with SUVmax.Results The expression of Glut1 and Ki-67 in CRC were higher than that in normal... |
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| Keywords: | Colorectal neoplasms Fluorodeoxyglucose F18 Positron-emission tomography Tomography, X-ray computed Glut1 Ki-67 |
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