艾普拉唑三联治疗幽门螺杆菌阳性十二指肠溃疡的近期疗效

目的：比较艾普拉唑与埃索美拉唑三联疗法治疗幽门螺杆菌（Hp）阳性十二指肠溃疡（DU）的近期疗效。方法：120例却阳性的DU患者随机分为3组，分别给予艾普拉唑15mg、20mg、埃索美拉唑20mg，同时给予克拉霉素0．5g、阿莫西林1．0g，bid，共10d。根除t／p结束后3组患者分别继续给予相应剂量质子泵抑制药治疗4周，于2周末和4周末复查胃镜并检测三和，观察患者溃疡愈合率、Hp根除率及药品不良反应。结果：2周末3组溃疡愈合率分别为82．5％、75％、77．5％（P〉0．05）；4周末溃疡愈合率分别为90％、87．5％、87．5％（P〉0．05）。3组Hp根除率分别为85％、82．5％、90％（P〉0．05）。3组均未见严重不良反应。结论：艾普拉唑三联疗法治疗Hp阳性DU能有效缓解症状，促进溃疡愈合，安全有效，疗效与剂量无明显线性关系，与埃索美拉唑临床疗效差异不明显。

Short-term Curative Effect of Ilaprazole-based Triple Therapy Regimens on Duodenal Ulcer with Helicobacter Pylori Infection

Objective:To compare the effect of ilaprazole- and esomeprazole-based triple therapy regimens on duodenal ulcer with helicobacter pylori(Hp) infection.Method:120 patients with duodenal ulcer with Hp infection were randomly divided into 3 groups,which were treated with ilaprazole 15,20 mg and esomeprazole 20 mg separately,and also given clarithromycin 500 mg and amoxicillin 1 000 mg at the same time twice daily for 10 days.After this treatment,all the patients were given the same dosage of corresponding PPI ...