子宫内膜异位症患者的红细胞免疫功能测定

目的 探讨子宫内膜异位症患者的抗子宫内膜抗体及红细胞免疫功能变化及临床意义。方法 将50例子宫内膜异位症患者研究对象，20例正常妇女为对照组，应用玫瑰花环试验检测红细胞补体C3b受体花环（C3bRR)及免疫复合物花环（ICR）2项红细胞免疫功能指标；应用ELISA法检测抗子宫内膜抗体。结果 与对照组比较，子宫内膜异位症各组C3bRR均明显降低（P＜0．05），ICR均明显升高（P＜0．05），子宫内膜异位症患者各组间C3bRR和ICR无显著差异，子宫内膜异位症患者抗子宫内膜抗体的阳性率明显升高（P＜0．05）。结论 子宫内膜异位症患者的红细胞免疫功能低下，可能与子宫内膜异位症的发生有关。抗子宫内膜抗体可以作为辅助诊断指标。

Investigation of erythrocyte immune function of patients with endometriosis

AimTo study erythrocyte immune function of patients with endometriosis and explore the pathogenesis of endometriosis Methods50 patients with endometriosis diagnosed by laparoscopy or laparotomy and 20 normal women as the control were studied The patients were divided into 3 groups according to the severity of the disease.Using rosette formation test, the erythrocyte immune function including C3b receptor rosette rate (C3bRR)and immune complex rosette rate(ICR) was determined. The antiendometrial antibody(EMAb) was detected by ELISA. ResultsThe C3bRR of patients was decreased and ICR was increased ( P <0 05) when compared with those of the control. C3bRR and ICR had no significant difference among three groups of patients.Positive rate of serum EMAb was increased( P <0 05)in patients when compared with the control. ConclusionThe erythrocyte immune function of patients with endometriosis is depressed. These changes of erythrocyte immune function may be related to the pathogenesis of endo metriosis. EMAb may be used as a marker of endometrosis.