| 青蒿素类似物的研究 Ⅶ.双(二氢青蒿素)醚和双(二氢脱氧青蒿素)醚类化合物的合成 |
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| 引用本文： | 陈一心,虞佩琳,李英,嵇汝运.青蒿素类似物的研究 Ⅶ.双(二氢青蒿素)醚和双(二氢脱氧青蒿素)醚类化合物的合成[J].药学学报,1985,20(6):470-473. |
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| 作者姓名： | 陈一心 虞佩琳 李英 嵇汝运 |
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| 作者单位： | 中国科学院上海药物研究所 |
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| 摘 要： | Some ethers, of bis(dihydroqinghaosu) Ⅲ and bis(dihydrodeoxyqinghaosu) Ⅳ were prepared in order to study the structure-activity relationships and to search for new antimalarials. Compounds Ⅲ were sythesized by condensation of glycol with two moles of dihydroqinghaosu using boron trifluoride etherate as catalyst. Compounds Ⅳ were prepared from ethers of bis (dihydroqinghaosu) by reduction with zinc and acetic acid.The bis-ethers were evaluated against chloroquine-resistant strain of plasmodium berghei in mice. Compounds Ⅲ were less potent than methyl-dihydroqinghaosu (Ⅰ) and compounds Ⅳ were inactive.
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| 关 键 词： | 抗疟药 杭氯喹虫株 双(二氢青蒿素) 醚 双(二氢脱氧青蒿素)醚 氢青蒿素甲醚 |
| 收稿时间： | 1984-05-21 |
Studies on analogs of qinghaosu. VII. The synthesis of ethers of bis(dihydroqinghaosu) and bis(dihydrodeoxyqinghaosu) |
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| CHEN Yi-Xin,YU Pei-Lin,LI Ying and JI Ru-Yun.Studies on analogs of qinghaosu. VII. The synthesis of ethers of bis(dihydroqinghaosu) and bis(dihydrodeoxyqinghaosu)[J].Acta Pharmaceutica Sinica,1985,20(6):470-473. |
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| Authors: | CHEN Yi-Xin YU Pei-Lin LI Ying and JI Ru-Yun |
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| Abstract: | Some ethers, of bis(dihydroqinghaosu) Ⅲ and bis(dihydrodeoxyqinghaosu) Ⅳ were prepared in order to study the structure-activity relationships and to search for new antimalarials. Compounds Ⅲ were sythesized by condensation of glycol with two moles of dihydroqinghaosu using boron trifluoride etherate as catalyst. Compounds Ⅳ were prepared from ethers of bis (dihydroqinghaosu) by reduction with zinc and acetic acid.The bis-ethers were evaluated against chloroquine-resistant strain of plasmodium berghei in mice. Compounds Ⅲ were less potent than methyl-dihydroqinghaosu (Ⅰ) and compounds Ⅳ were inactive. |
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| Keywords: | Chloroquine-resistant strain of plasmodium berghei Ethers of bis(dihydroqinghaosu) Ethers of bis(dihydrodeoxyqinghaosu) methyldihydroqinghaosu Antimalarials |
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