阿昔洛韦联合蒲地兰消炎口服液治疗肠道病毒71型手足口病疗效观察

目的：观察阿昔洛韦联合蒲地兰消炎口服液治疗肠道病毒71型手足口病的临床疗效。方法：将100例患儿随机分为对照组50例和治疗组50例，治疗组给予阿昔洛维10mg／kg加入5％葡萄糖注射液250mi静脉滴注，每日1次；蒲地兰口服液口服，3次／d．连服6—12d，具体用量：小于等于1岁患儿每次1／3支，1-2岁患儿每次1／2支，2～4岁患儿每次2／3支，4～5岁患儿每次1支。对照纽仅给予阿昔洛维注射液治疗。两组均采用补液、对症等治疗，少数病例疑合并细菌感染者加用抗菌药物抗感染治疗，并观察两组疗效。结果：退热、咽痛消失、疱疹消退、EV71转阴及治愈时间治疗组均优于对照组（P〈0．05）。结论：阿昔洛韦联合蒲地兰口服液治疗肠道病毒71型手足口病具有较好临床疗效。

Aciclovir combined with Pu Di Lan Xiao Yan Kou Fu Ye in patients with EV71Hand, Foot And Mouth Disease

Objective ： to observe efficacy of Aciclovir combined with Pu Di Lan Xiao Yan Kou Fu Ye for patients with EV71 hand, foot and mouth disease. Methods： 100 patients with EV71 HAMD were randomly divided to treatment group （TG,50）and control group （CG,50）. In ad- dition to the usual treatment,TG Group was given Aciclovir combined with Pu Di Lan Xiao Yan Kou Fu Ye and CG group was only given Aciclovir while observing the time of tempreture ,herpes disappearing ,curing and EV71 minus. Results： TG＇s clinical cure rate was 36% and total effective rate 94%. CG＇s clinical cure rate was22% and total effective rate 80%. TG was significantly higher than CG（P〈0.05）. Conclusion：Aciclovir combined with Pu Di Lan Xiao Yan Kou Fu Ye in patients with EV71 hand, foot and mouth disease is markedly effective.