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甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响
引用本文:段金虹,程锦轩,程喆人,韩凤云,王振钢. 甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响[J]. 中国药理学通报, 1991, 0(6)
作者姓名:段金虹  程锦轩  程喆人  韩凤云  王振钢
作者单位:中国医学科学院基础医学研究所药理室 北京100730(段金虹,程锦轩,韩凤云),辽宁省抚顺市第三医院 进修生(程喆人),中国医学科学院基础医学研究所药理室 北京100730(王振钢)
摘    要:本文测定了不同浓度的甘草酸单铵(AG)对体外培养人和大鼠淋巴细胞的~3H胸腺嘧啶核苷(~3HTdR)参入抑制率及PGI_2和TXA_2合成的影响。结果表明:AG在1.5×10~(-7)和3×10~(-7)时增加~3HTdR参入抑制率。利用RIA方法测定了AG对淋巴细胞PGI_2和TXA_2的影响,发现在4×10~(-7)mol/L、4×10~(-8)mol/L和4×10~(-11)mol/L的AG作用下,可显著降低TXA_2的释放,而对PGI_2的释放无显著影响。

关 键 词:甘草酸单铵  胸腺嘧啶核苷  淋巴细胞  前列环素  血栓素A_2

THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES
Duan Jinhong,Cheng Jinxuan,Cheng jiren. THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES[J]. Chinese Pharmacological Bulletin, 1991, 0(6)
Authors:Duan Jinhong  Cheng Jinxuan  Cheng jiren
Abstract:The influences of varied concentrations of AG on the 8H-TdR(3H-Thymidine ) incorporation inhibition rate and the release of PGI2 and TXA2 were studied in cultured human and rat lymphocytes . The results indicated that the AG increased the 3H-TdR incorporation inhibition rate on the concentrations of 1.5× 10-7mol/L and 3×10-7mol/L. Using the RIA method, authors find that AG on the concentrations of 4 × 10-7mol/L, 4 × 10-3mol/L and 4 × 10-11mo/L can significantly decrease the cultured lymphocytes TXA2 release while has no clear influences on PGI2 release
Keywords:Ammonium Glycyrrnizanate ( AG )  3H-Thymidine ( 3H-TdR)  Lymphocytes  Prostacycin ( PGI2 )  Thromboxane A2 (TXA2)
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