| 甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响 |
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| 引用本文： | 段金虹,程锦轩,程喆人,韩凤云,王振钢.甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响[J].中国药理学通报,1991(6). |
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| 作者姓名： | 段金虹 程锦轩 程喆人 韩凤云 王振钢 |
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| 作者单位： | 中国医学科学院基础医学研究所药理室 北京100730
(段金虹，程锦轩，韩凤云)，辽宁省抚顺市第三医院 进修生
(程喆人)，中国医学科学院基础医学研究所药理室 北京100730(王振钢) |
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| 摘 要： | 本文测定了不同浓度的甘草酸单铵(AG)对体外培养人和大鼠淋巴细胞的~3H胸腺嘧啶核苷(~3HTdR)参入抑制率及PGI_2和TXA_2合成的影响。结果表明:AG在1.5×10~(-7)和3×10~(-7)时增加~3HTdR参入抑制率。利用RIA方法测定了AG对淋巴细胞PGI_2和TXA_2的影响,发现在4×10~(-7)mol/L、4×10~(-8)mol/L和4×10~(-11)mol/L的AG作用下,可显著降低TXA_2的释放,而对PGI_2的释放无显著影响。
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| 关 键 词： | 甘草酸单铵 胸腺嘧啶核苷 淋巴细胞 前列环素 血栓素A_2 |
THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES |
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| Duan Jinhong,Cheng Jinxuan,Cheng jiren.THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES[J].Chinese Pharmacological Bulletin,1991(6). |
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| Authors: | Duan Jinhong Cheng Jinxuan Cheng jiren |
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| Abstract: | The influences of varied concentrations of AG on the 8H-TdR(3H-Thymidine ) incorporation inhibition rate and the release of PGI2 and TXA2 were studied in cultured human and rat lymphocytes . The results indicated that the AG increased the 3H-TdR incorporation inhibition rate on the concentrations of 1.5× 10-7mol/L and 3×10-7mol/L. Using the RIA method, authors find that AG on the concentrations of 4 × 10-7mol/L, 4 × 10-3mol/L and 4 × 10-11mo/L can significantly decrease the cultured lymphocytes TXA2 release while has no clear influences on PGI2 release |
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| Keywords: | Ammonium Glycyrrnizanate ( AG ) 3H-Thymidine ( 3H-TdR) Lymphocytes Prostacycin ( PGI2 ) Thromboxane A2 (TXA2) |
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