比索洛尔对原发性高血压患者肾素-血管紧张素-醛固酮系统及血管内皮功能的影响

为研究比索洛尔的降压疗效及其对肾素 血管紧张素 醛固酮系统及血管内皮功能的影响 ,选择 72例初诊原发性高血压病人口服比索洛尔 4周 ,观察治疗前后诊室血压及血浆肾素、血管紧张素Ⅱ、醛固酮、内皮素质量浓度和一氧化氮浓度的变化。发现 :比索洛尔治疗 4周后 ,诊室收缩压和舒张压的下降幅度分别为 2 .16kPa( 16 .2 3mmHg)和 1.0 2kPa( 7.6 5mmHg) ,与服药前相比差异有非常显著性 (P <0 .0 1) ;肾素、血管紧张素Ⅱ、醛固酮降低 ,一氧化氮升高 (P <0 .0 5) ;而内皮素、一氧化氮 /内皮素比值无明显变化。提示 :比索洛尔能够有效抑制肾素、血管紧张素、醛固酮系统及改善血管内皮功能 ,达到降低血压和保护靶器官的目的

Effects of Bisoprolol on renin-angiotensin System and Vascular Endothelial Function in Patients with Essential Hypertension

To investigate the effects of bisoprolol on renin-angiotensin-aldosterone syst em(RAAS), endothelial function and its antihypertensive efficacy, the changes of plasma endothelin (ET), nitrogen monoxide(NO), renin(Ren), angiotensin Ⅱ(AngⅡ), aldosterone(Ald) and clinical blood pressure(CBP) were observed before and a fter bisoprolol was taken for 4 weeks in 36 patients with essential hypertension . After 4 weeks treatment of bisoprolol, clinical systolic b lood pressure and clinical diastolic blood pressure decreased to 2.16 kPa(16.23 mmHg) a nd 1.02 kPa(7.65 mmHg) respectively(P< 0.01); Ren, AngⅡ, Ald decreas ed and NO significantly increased(P<0.05 and 0.01 respectively), but NO/ET and ET h ad no any changes(P>0.05). It is suggested that Bisoprolol can not only dec rease blood pressure, but also inhabit RAAS,improve vascular endothelial functi on and protect target organ simultaneously.