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In vitro activity of telithromycin against macrolide-susceptible and macrolide-resistant pharyngeal isolates of group A streptococci in the United States |
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| Authors: | Green Michael Allen Coburn Bradley John Dashefsky Barry Gilsdorf Janet R Marcon Mario J Schutze Gordon E Smith Clay Walter Emmanuel Martin Judith M Edwards Kathryn A Barbadora Karen A Rumbaugh Renee M Wald Ellen R |
| Affiliation: | Department of Pediatrics, MPH Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. michael.green@chp.edu |
| Abstract: | In vitro susceptibility testing of 2,797 group A streptococcus (GAS) isolates demonstrated that telithromycin was fully active against all macrolide-susceptible strains and among 80 of 115 macrolide-resistant GAS expressing the M phenotype. Telithromycin resistance was identified in 2 of 45 strains expressing the inducible macrolide-lincosamide-streptogramin B phenotype and four of nine isolates expressing the constitutive macrolide-lincosamide-streptogramin B resistance phenotype. |
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