胶原在心血管疾病作用的研究进展

心脏细胞外基质 (ECM)中主要为 、 型胶原( 型占 85 %、 型占 11% )及纤连蛋白等 ,它构成心脏三维结构 ,决定了心脏组织的伸展性和弹性。几十年研究结果发现 ECM并不是一个惰性系统 ,而处于动态的合成、降解过程 ,心血管胶原网的作用逐渐被认识。本文就胶原和高血压、心肌梗死及血管成形术等心血管疾病关系作一综述。1　胶原性状及功能1.1　胶原性状 :成纤维细胞首先合成 、 型前胶原 ,较大的前体含有羧基端 (C端 )和氨基端 (N端 )前肽。C端前肽含有非胶原氨基酸 ,呈球形 ,N端前肽含有短胶原氨基酸顺序 ,呈三维螺旋结构 ,分泌入细胞外…

The Effects of Collagen in Cardiovascular Diseases

Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after myocardial infarction in the transition to heart failure, and during the progression of left ventricular dysfunction. This report discusses most recent experimental findings and focuses on the alterations in nonmyocytic elements that are a part of heart involvement. Particular attention was given to factors that are responsible for exaggerated myocardial deposition of collagen that may be responsible for ventricular dysfunction.