FE复合溶菌酶治疗烧伤后期感染残余创面的临床研究

目的确证FE复合溶菌酶对烧伤后期残余创面杀菌作用与促愈作用。方法选取笔者单位烧伤残余创面患者30例，随机分为治疗组，用无菌纱布浸湿FE复合溶菌酶后湿敷创面。对照组用庆大霉素盐水纱布湿敷创面，2次／d。于用药前后取创面分泌物培养，观察FE复合溶菌酶对创面细菌敏感率并观察愈合时间及肝肾功情况。结果FE复合溶菌酶应用3d后，能杀死残余创面中89．9％的细菌，治疗组愈合时间明显短于对照组。差异有统计学意义（P〈0．01）使用后未见全身不良反应。结论FE复合溶菌酶治疗烧伤后期残余创面安全有效，可以有效控制残余创面感染，提高创面愈合率。

Clinical observation of the effects of combined FE enzymes in the treatment of residual infected burn wounds at late postburn stage

Objective To confiming the effect of combined FE combined enzymes in the treatment of residual infected burn wounds at late postburn stage.Methods Thirty patients with residual wounds at late postburn stage were enrolled in the study,and they were randomly divided into A(treated with combined FE combined enzymes)and B( treated with gentamicin)groups,with 15 patients in each group,several layers of gauze,either soaked with combined FE combined enzymes in A or gentmnicin in B group,were used to cover the residual wounds at late postbum stage once to twice a day.Bacterial culture from the burn wounds exudation before and after drug administration was done before the application of the agents.Susceptibility of the bacteria to antibiotics were identified.The healing time of the burn wounds was recorded,and also bepatia and renal functions of the patients were examined.Results Eighty-nine percent bacteria could be killed by FE combined enzymes after gauze with FE enzymes had been used for over 3 d.The wound healing time the residual wounds at late posthurn stage in A group was siginificandy shorter than that in B group.No adverse side-effects were observed in either group.Condusion Combined FE combined enzymes is safe and effective for the elimination of residual wounds at late postbum stage,and it is beneficial to control wound infection and promote the wound healing.