非小细胞肺癌骨转移化疗后的骨髓抑制分析

目的：观察晚期非小细胞肺癌骨转移患者化疗后的骨髓抑制程度.方法：将247例晚期非小细胞肺癌患者分为两组,研究组为伴骨转移的患者132例,对照组为无骨转移的患者115例,化疗1周期,进行骨髓抑制和其他不良反应的比较.结果：研究组中化疗后Ⅲ-Ⅳ度白细胞、血小板、红细胞下降的患者比例分别是28.8％、31.1％和20.5％,对照组为15.7％、14.8％和13.0％,差异有统计学意义（P＜0.05）.研究组出现骨髓抑制最严重的平均时间为9天,对照组12天,差异有统计学意义（P＜0.05）.Ⅲ-Ⅳ度恶心、呕吐和流感样症状恶心、呕吐研究组为31.8％、8.3％,对照组为19.1％、1.7％,差异有统计学意义（P＜0.05）.结论：晚期非小细胞肺癌骨转移化疗后更易发生严重的骨髓抑制,且时间提前;恶心、呕吐及流感样症状程度较严重,应注意化疗剂量的调整.

Bone marrow suppression of non-small cell lung cancer with bone metastasis after chemotherapy

Objective：To observe the degree of bone marrow suppression of advanced non - small cell lung cancer patients with bone metastasis. Methods：All 247 advanced non - small cell lung cancer patients were divided into two groups ：the study group has 132 cases of bone metastases ,and the control group has 115 cases of no bone metastases. After one cycle chemotherapy, bone marrow suppression and other adverse reaction were compared. Results：After chemotherapy, the rate of Ⅲ - Ⅳ degrees of white blood ceils, platelets, red blood cells dropping in study group were 28.8% ,31.1% and 20.5% ,in control group were 15.7%, 14.8% and 13.0% ,the difference was statistically sig- nificant（P 〈 0.05）. The average day of the most serious bone marrow suppression was 9 days in study group, and 12 days in control group （ P 〈 0.05 ）. Ⅲ - Ⅳ nausea, vomiting and flu - like symptoms nausea, vomiting in research group were 3 I. 8%, 8.3%, in control group were 19.1%, and 1.7%, the difference was statistically significant （P 〈 0.05）. Conclusion： Advanced non - small cell lung cancer with bone metastasis after chemotherapy more easily ap- pear serious bone marrow suppression, and ahead of time. Nausea, vomiting and flu - like symptoms are more serious. So we should pay attention to adjustment of chemotherapy doses.