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Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy |
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| Authors: | Mario Moro Caterina Giannini Dr Bernd W Scheithauer Ricardo V Lloyd Paul Restall Carl Eagleton Andrew J Law Kalman Kovacs |
| Institution: | (1) Department of Pathology, Mayo Clinic, Rochester, MN;(2) Department of Pathology, Auckland Hospital, Auckland, New Zealand;(3) Department of Endocrinology, Auckland Hospital, Auckland, New Zealand;(4) Department of Neurosurgery, Auckland Hospital, Auckland, New Zealand;(5) St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada;(6) Department of Pathology and Laboratory Medicine, 200 First Street, SW, 55905 Rochester, MN, USA |
| Abstract: | We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies. |
| Keywords: | Pituitary fibrosarcoma prolactin cell adenoma with neuronal metaplasia pituitary adenoma/neuronal choristoma (PANCH) |
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