Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome |
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| Authors: | Lili Zhang Li Cui Chunmei Li Xiangzhong Zhao Xiaoying Lai Jing Li Teng Lv |
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| Affiliation: | aDepartment of Nutrition, The Affiliated Hospital of Qingdao University, Qingdao, China;bDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China;cMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China;dDepartment of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China |
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| Abstract: | The aim of this research was to examine the clinical characteristics of acute kidney injury (AKI) in primary nephrotic syndrome (NS) and discuss the relationship between serum lipids and AKI. A total of 1028 patients diagnosed with primary NS with renal biopsy results were enrolled in this study. The patients were divided into AKI (n = 81) and non-AKI (n = 947) groups, and their characteristics were compared using a propensity score analysis for the best matching. Serum free fatty acid (FFA) was an independent predictor for AKI in the postmatch samples (p = 0.011). No significant difference in FFA levels was observed among AKI stages or different pathological types in the AKI and non-AKI groups. The AUC (area under the ROC curve) was 0.63 for FFA levels to distinguish AKI. In primary NS, elevated FFA levels tend to be related to a high risk of AKI. FFAs have diagnostic value and may serve as biomarkers for AKI in NS. |
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| Keywords: | Acute kidney injury fatty acid nephrotic syndrome biomarker acute tubular necrosis |
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