Rho GTP酶通过树突棘介导阿尔茨海默病认知功能障碍的研究进展

<正>阿尔茨海默病(Alzheimer’s disease, AD)是一种进行性神经系统退行性疾病，其临床表现为记忆、注意等认知功能障碍和行为改变[1],AD是最常见的老年痴呆类型。随着人口老龄化的深化，AD发病率不断增加，给人们的生活和社会运转造成了严重负担[2]。目前AD尚无治愈方法，公认的治疗方法包括胆碱酯酶抑制剂和N-甲基-D-天冬氨酸受体拮抗剂的应用，但这些药物均局限于缓解症状[3]。

Rho GTPase mediates cognitive dysfunction in Alzheimer''s disease through dendritic spines

Alzheimer''s disease (AD) is a progressive neurodegenerative disease. Its clinical manifestations are cognitive dysfunction and behavioral changes such as memory and attention [1]. Ad is the most common type of Alzheimer''s disease. With the deepening of population aging, the incidence of ad is increasing, which has caused a serious burden on people''s life and social operation [2]. At present, there is no cure for AD, and the accepted treatment methods include the application of cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists, but these drugs are limited to relieve symptoms [3].