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| γ-干扰素诱导Jurkat细胞表达B7.1/CD80、B7.2/CD86分子 | |
| 引用本文： | 戴振声,陈勤奋,谢弘,谢毅. γ-干扰素诱导Jurkat细胞表达B7.1/CD80、B7.2/CD86分子[J]. 中国生化药物杂志, 2001, 22(6): 287-289 |
| 作者姓名： | 戴振声 陈勤奋 谢弘 谢毅 |
| 作者单位： | 1. 复旦大学,医学院,附属华山医院,血液科,上海,200040;中国科学院,上海细胞生物学研究所,上海,200031 2. 复旦大学,医学院,附属华山医院,血液科,上海,200040 3. 中国科学院,上海细胞生物学研究所,上海,200031 |
| 摘 要： | 目的研究观察γ 干扰素 (γ IFN)诱导Jurkat细胞株表达B7.1、B7.2分子的作用。方法不同浓度的γ IFN体外孵育Jurkat细胞 48h后 ,流式细胞仪检测细胞表达B7.1、B7.2的百分率。结果与对照组相比 ,γ IFN在312 .5～ 10 0 0 0u/ml浓度下有轻微提高Jurkat淋巴白血病细胞表达B7.1、B7.2分子的作用。在 2 5 0 0u/ml浓度时达到高峰 ,B7.1的表达比对照组提高 3.47% ,B7.2表达提高 2 .39% ,B7.1与B7.2双表达提高 1.85 %。结论γ IFN可轻度诱导Jurkat细胞表达B7.1、B7.2分子 |
| 关 键 词： | γ干扰素 Jurkat细胞株 B7.1 B7.2 |
| 文章编号： | 1005-1678(2001)06-0287-03 |
| 修稿时间： | 2001-03-05 |
-interferon inducing B7.1,B7.2 expression on Jurkat cell line |
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| DAI Zhen sheng ,,CHEN Qin fen ,XIE Hong ,XIE Yi. -interferon inducing B7.1,B7.2 expression on Jurkat cell line[J]. Chinese Journal of Biochemical Pharmaceutics, 2001, 22(6): 287-289 | |
| Authors: | DAI Zhen sheng CHEN Qin fen XIE Hong XIE Yi |
| Affiliation: | DAI Zhen sheng 1,2,CHEN Qin fen 1,XIE Hong 2,XIE Yi 1 |
| Abstract: | PurposeThe aim is to investigate γ interferon′s effects on B7.1, B7.2 expression on Jurkat cell line.MethodsJurkat cells were collected for FCM scan after having been incubated with various concentrations of γ interferon for 48 hours. ResultsCompared with the control, γ interferon slightly enhanced the expression of B7.1, B7.2 on Jurkat cells′ surface within the concentration from 312.5 u/ml to 10 000 u/ml . The effect reached its peak at the concentration of 2 500 u/ml, the expression of B7.1 was raised by 3.47% and which of B7.2 was raised by 2.39%, co expression of B7.1 and B7.2 was raised by 1.85%.Conclusionγ interferon could slightly induce the expression of B7.1, B7.2 on Jurkat cells. |
| Keywords: | interferon Jurkat cell line B7.1 B7.2 |
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