| 交联剂在抑制基质金属蛋白酶与提高粘接耐久性领域的研究进展 |
| |
| 引用本文： | 鄢晓媛,陈玥,李轲,郑适泽,战德松,付佳乐. 交联剂在抑制基质金属蛋白酶与提高粘接耐久性领域的研究进展[J]. 中华口腔医学研究杂志(电子版), 2019, 13(5): 311-316. DOI: 10.3877/cma.j.issn.1674-1366.2019.05.009 |
| |
| 作者姓名： | 鄢晓媛 陈玥 李轲 郑适泽 战德松 付佳乐 |
| |
| 作者单位： | 1. 中国医科大学口腔医学院，沈阳 1100022. 吉林大学口腔医学院，长春 1300213. 中国医科大学口腔医学院口腔材料学教研室，中国医科大学附属口腔医院修复二科，沈阳 110002 |
| |
| 摘 要： | 基质金属蛋白酶（MMP）能够降解牙本质胶原纤维，是影响牙科粘接修复耐久性的重要因素。因此，抑制牙本质MMP的活性是提高粘接耐久性的关键。作为一种MMP抑制剂，交联剂不仅能够抑制MMP活性，还具备促进牙本质胶原纤维交联的作用，上述双重作用使交联剂能够提高牙本质粘接的耐久性。本文就常见交联剂在抑制MMP与提高牙本质粘接耐久性方面的研究进展进行综述。
|
| 关 键 词： | 基质金属蛋白酶类 酶抑制剂 交联试剂 牙本质粘接剂 牙粘合 粘接耐久性 |
| 收稿时间： | 2019-05-09 |
Research progress of crosslinkers in inhibiting matrix metalloproteinases and improving bonding durability |
| |
| Xiaoyuan Yan,Yue Chen,Ke Li,Shize Zheng,Desong Zhan,Jiale Fu. Research progress of crosslinkers in inhibiting matrix metalloproteinases and improving bonding durability[J]. Chinese Journal of Stomatological Research(Electronic Version), 2019, 13(5): 311-316. DOI: 10.3877/cma.j.issn.1674-1366.2019.05.009 |
| |
| Authors: | Xiaoyuan Yan Yue Chen Ke Li Shize Zheng Desong Zhan Jiale Fu |
| |
| Affiliation: | 1. School of Stomatology, China Medical University, Shenyang 110002, China2. School of Stomatology, Jilin University, Changchun 130021, China3. Department of Dental Materials Science, The 2nd Department of Prosthodontics, School & Hospital of Stomatology, China Medical University, Shenyang 110002, China |
| |
| Abstract: | The matrix metalloproteinases (MMPs) can degrade dentin collagen fibers, which plays an important role in affecting the bonding durability of dental restoration. Therefore, inhibiting the activity of dentin MMPs is the key to improve bonding durability. As inhibitors of MMPs, cross-linking agents can not only inhibit the activity of MMPs, but also promote the crosslinking of dentin collagen fibers. These two functions enable cross-linkers to improve dentin bonding. In this article, the research progress of common cross-linking agents in inhibiting MMPs and improving bonding durability of dentin was reviewed. |
| |
| Keywords: | Matrix metalloproteinases Enzyme inhibitors Cross-linking reagents Dentin bonding agents Dental bonding Bonding durability |
|
| 点击此处可从《中华口腔医学研究杂志(电子版)》浏览原始摘要信息 |
|
点击此处可从《中华口腔医学研究杂志(电子版)》下载全文 |
