| 高密度脂蛋白3与急性冠状动脉综合征相关性临床分析 |
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| 引用本文： | 范婷婷,何非,王晓晨. 高密度脂蛋白3与急性冠状动脉综合征相关性临床分析[J]. 蚌埠医学院学报, 2019, 44(10): 1319-1321. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.007 |
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| 作者姓名： | 范婷婷 何非 王晓晨 |
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| 作者单位： | 安徽医科大学第二附属医院 心内科,安徽 合肥,230601;安徽医科大学第二附属医院 心内科,安徽 合肥,230601;安徽医科大学第二附属医院 心内科,安徽 合肥,230601 |
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| 基金项目： | 安徽省自然科学基金项目1808085QH235 |
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| 摘 要： | 目的分析高密度脂蛋白3（HDL3）与急性冠状动脉综合征（ACS）及其严重程度的相关性。方法根据冠状动脉造影结果将研究对象分为正常对照组（n=47）、稳定性心绞痛组（SAP，n=58）和急性冠状动脉综合征组（ACS，n=130）。采用酶联免疫吸附法检测血清中HDL3的含量，分析HDL3与ACS及其严重程度的相关性。结果3组研究对象血清HDL3水平差异有统计学意义，ACS组HDL3水平低于SAP组（P < 0.05）。回归分析显示血清HDL3水平与ACS的严重程度呈显著负相关关系（P < 0.01）。结论血清HDL3水平与ACS的严重程度呈显著负相关关系，HDL3是ACS的保护因素。
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| 关 键 词： | 急性冠状动脉综合征 高密度脂蛋白胆固醇 高密度脂蛋白3 |
| 收稿时间： | 2019-02-25 |
Clinical analysis of the correlation between serum level of high density lipoprotein 3 and acute coronary syndrome |
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| Affiliation: | Department of Cardiovascular Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei Anhui 230601, China |
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| Abstract: | ObjectiveTo analyze the correlation between serum level of high density lipoprotein 3 (HDL3) and acute coronary syndrome (ACS).MethodsTwo hundred and thirty-five patients were divided into the control group(n=47), stable angina pectoris group(SAP group, 58 cases) and ACS group(n=130) according to the results of coronary angiography.The serum levels of HDL3 in three groups were measured using ELISA, and the correlation between serum level of HDL3 and ACS was analyzed.ResultsThe differences of the serum levels of HDL3 among three groups were statistically significant, the serum level of HDL3 in ACS group was lower than that in SAP group (P < 0.05).The results of regression analysis showed that the serum level of HDL3 was negatively correlated with the severity of ACS (P < 0.01).ConclusionsThe serum level of HDL3 is negatively correlated with the severity of ACS, and HDL3 is an independent protective factor of ACS. |
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