血清降钙素原与超敏C反应蛋白及白细胞计数在儿童早期感染中的诊断价值

目的探讨血清降钙素原（PCT）与超敏C反应蛋白（hs-CRP）及白细胞计数（WBC）在儿童早期感染中的诊断价值。方法选取2017年3月至2018年3月感染性疾病患儿160例，根据感染病原纳入病毒组（75例）和细菌组（85例），同时选取60名健康体检儿童纳入健康对照组，测定并比较各组儿童血清PCT、hs-CRP水平及WBC计数，计算并绘制三个指标的灵敏度、特异度和受试者工作特征（ROC）曲线。结果3组儿童血清PCT、hs-CRP及WBC测定值比较，组间差异均有统计学意义（P < 0.01）；细菌组患儿血清PCT、hs-CRP及WBC测定值较病毒组和健康对照组明显上升，病毒组患儿血清PCT、hs-CRP及WBC测定值明显高于健康对照组（P < 0.01）；PCT用于诊断细菌感染的ROC曲线下面积为1，灵敏度为100%，特异度为100%，均大于hs-CRP及WBC。结论血清PCT、hs-CRP及WBC在患儿早期细菌性感染疾病中均有一定的诊断价值，并且PCT的灵敏性和特异性更高，其诊断价值优于hs-CRP和WBC。

Diagnostic value of the serum levels of procalcitonin and high sensitivity C reactive protein,and white blood cell count in early childhood infection

ObjectiveTo investigate the diagnostic value of the serum levels of procalcitonin(PCT) and high sensitivity C reactive protein(hs-CRP) and white blood cell count(WBC) in early childhood infection.MethodsOne hundred and sixty children with infectious diseases from March 2017 to March 2018 were divided into the virus group(75 cases) and bacterial group(85 cases) according to the infection pathogen, and 60 healthy children were set as the healthy control group.The serum levels of PCT, hs-CRP and WBC were measured and compared among three groups, and the sensitivity, specificity and receiver operating characteristic(ROC) curves of three indexes were calculated and plotted.ResultsThe differences of the serum levels of PCT and hs-CRP, and WBC value among three groups were statistically significant(P < 0.05).The serum levels of PCT and hs-CRP, and WBC in bacteria group were significantly higher than those in virus group and healthy control group, and the serum levels of PCT and hs-CRP, and WBC in viral group were significantly higher than those in healthy control group(P < 0.01).When the PCT was used to diagnose the bacterial infections, the area under the ROC curve of PCT, sensitivity and specificity were 1, 100% and 100%, respectively, and which was greater than whose of hs-CRP and WBC.ConclusionsThe serum levels of PCT and hs-CRP, and WBC have certain diagnostic value in early bacterial infection in children.Moreover, the sensitivity and specificity of PCT are higher, and the diagnostic value of PCT is better than that of hs-CRP and WBC.