支架取栓联合动脉内溶栓治疗急性脑动脉闭塞的效果

目的观察支架取栓联合动脉内溶栓治疗急性脑动脉闭塞的临床效果。方法选取2015年5月至2017年5月泰安市中心医院就诊的急性脑动脉闭塞患者90例,进行前瞻性研究。采用随机数字表法将患者分为对照组和试验组两组,每组45例。对照组患者采用单纯动脉内溶栓治疗,其中男性28例,女性17例;年龄35-65岁,平均(54.64±5.35)岁。试验组患者采用支架取栓联合动脉内溶栓治疗,其中男性26例,女性19例;年龄34~66岁,平均(55.43±5.73)岁。比较两组患者治疗前后不同时期美国国立卫生院神经功能缺损评分(NIHSS)、日常生活能力量表评分(ADL)改善情况以及支架取栓联合动脉内溶栓治疗的安全性。结果与治疗前相比,两组患者治疗后7 d NIHSS评分均降低(P<0.05),90 dADL评分则升高(P<0.05),且试验组患者的NIHSS评分低于同期对照组(P<0.05),其ADL评分则高于对照组(P<0.05)。试验组患者血管再通情况优于对照组(P<0.05),其颅内出血、症状性颅内出血以及90 d内死亡等不良事件的发生率低于对照组(P<0.05),组间差异有统计学意义。结论支架取栓联合动脉内溶栓治疗急性脑动脉闭塞能明显改善患者的血流状态,提高血管再通率,减少颅内出血的发生,保障患者的预后疗效和生活质量。

Effect of stent thrombolysis on acute cerebral artery occlusion

ObjectiveTo explore the clinical effect of stent thrombolysis in the treatment of acute cerebral artery occlusion. MethodsFrom May 2015 to May 2017, 90 patients visiting to the Taian Central Hospital with acute cerebral arterial occlusion were chosen in this prospective study. Using the random number table method we divided the patients into two groups: control group and test group; control group was treated by simple artery thrombolysis, and treatment group was gived by support bolt joint arterial thrombolysis. The efficacy of patients was compared between the two groups before and after treatment with the National Institutes of Health Neural Function Defect Scores(NIHSS), Daily Life Ability Rating Scales (ADL) scores and the safety, respectively. ResultsCompared with that before treatment, two groups of patients showed that the NIHSS scores were decreased (P<0.05) and ADL scores were increased (P<0.05). The test group of NIHSS scores were lower than that of the control group (P <0.05), the ADL scores were higher than that of the control group (P<0.05). Recanalization in patients with the treatment group was better than that of the control group (P<0.05). The intracranial hemorrhage, symptomatic intracranial hemorrhage and the incidence of adverse events such as death within 90 days were lower than those of the control group (P<0.05), with statistically significant difference between the groups. ConclusionsThe stent joint artery thrombolysis in the treatment of acute cerebral artery occlusion can obviously improve the patient's blood flow state and the rate of blood vessels, reduce the incidence of intracerebral haemorrhage, and then ensure the conditions of prognosis and quality of life.