血管生成拟态在直肠腺癌中的临床病理意义

目的通过搜集相关资料研究直肠腺癌中血管生成拟态(VM)是否存在及其相关临床病理意义。方法收集176例直肠腺癌相关临床病理资料，利用免疫组织化学EliVisionTM plus的方法，观察其中是否存在VM，将其分成阳性和阴性2组，分析VM的存在是否与相关临床病理指标之间有关。结果176例组织标本中35例VM为阳性，阳性率为19.89%，不同性别、年龄组及肿瘤的长径间VM的形成差异均无统计学意义(P＞0.05)；而在低分化组、伴有血管、神经侵犯组、伴有淋巴结转移组的VM阳性率显著较高(P＜0.01)。多因素回归分析表明VM的阳性表达率越高，病人的生存时间越短(P＜0.01)；有淋巴结转移的病人比无淋巴结转移的病人生存时间短(P＜0.01)；有血管、神经侵犯的病人比无血管、神经侵犯的病人生存时间短(P＜0.05)。结论VM存在于直肠腺癌中，且VM的形成对直肠腺癌的发生、发展及其预后都具有重要的意义。

Clinical pathological significance of vasculogenic mimicry in rectal adenocarcinoma

Objective To study the presence or absence of vasculogenic mimicry(VM) in rectal adenocarcinoma by some relevant data, and explore its clinical and pathological significance.MethodsThe clinicopathological data of 176 patients with rectal adenocarcinoma were collected.The VM was detected using immunohistochemical EliVisionTM plus method, and the cases were divided into the positive and negative groups.The relationship between VM and clinicopathological parameters was analyzed.Results Among 176 tissue samples, the positive expression of VM in 35 cases was identified, and the positive rate of which was 19.89%.The differences of the formation of VM among different gender, age and length of tumor were not statistically significant(P>0.05).The positive rates of VM in poor differentiation group, vascular and nerve invasion group and lymph node metastasis group significantly increased(P < 0.01).The Results of multivariate regression analysis showed that the survival time of patients became short with the increasing of the positive rate of VM(P < 0.01), the survival time of patients with lymph node metastasis was shorter than that in patients without lymph node metastasis(P < 0.01), and the survival time of patients with vascular and nerve invasion was shorter than that in patients without vascular and nerve invasion(P < 0.05).Conclusions VM is present in rectal adenocarcinoma, and the formation of VM is of great significance to the occurrence, development and prognosis of rectal adenocarcinoma.