婴幼儿及学龄前儿童热性惊厥与缺铁性贫血关联的Meta分析

目的通过对已发表的文章进行荟萃分析以明确婴幼儿及学龄前儿童发生热性惊厥与缺铁性贫血的关系。 方法利用PubMed、Web of science、MEDLINE、万方数据知识服务平台、中国知网数据库(CNKI)、维普等数据库数据库(VIP)和Cochrane图书馆数据库等中英文电子数据库,收集1990年1月至2017年9月前已发表的关于3个月至6岁婴幼儿及学龄前儿童发生热性惊厥与缺铁性贫血相关性的文章。按纳入与排除标准由2名研究者阅读全文后进行文献筛选和资料提取,采用纽卡斯尔-渥太华量表(the Newcastle-Ottawa Scale,NOS)进行文献质量评估。Stata SE 12.0软件对缺铁性贫血是否为热性惊厥患儿风险因素进行Meta分析,计算比值比(OR),并依据缺铁性贫血诊断标准的不同进行亚组分析。 结果本研究共检出相关文献89篇,排除重复和不相关的搜索记录11篇、只有摘要的文章18篇,以及对全文进行排查：综述2篇、缺少数据9篇以及数据雷同2篇剔除,最终纳入符合纳入与排除标准的26篇文献进行Meta分析。分析结果表明：热性惊厥与缺铁性贫血具有相关性[OR＝2.24,95%CI(1.758,2.854),P<0.05]。 结论缺铁性贫血是婴幼儿及学龄前儿童发生热性惊厥的风险因素之一。

Association between febrile seizures and iron deficiency anemia in infants and preschool children: a Meta-analysis

ObjectiveTo determine the relationship between febrile seizures and iron deficiency anemia in infants and preschool children by using a meta-analysis of published articles. MethodsThe Chinese and English electronic databases were used in this study, such as PubMed, Web of science, MEDLINE, Wanfang Data Knowledge Service Platform, China Knowledge Network Database (CNKI), VIP Database, and Cochrane Library Database, collected from January 1990 to September 2017. The published articles about the association between febrile seizures and iron deficiency anemia in infants and preschool children between 3 months and 6 years old were reviewed. The search terms in Chinese were "iron deficiency" or "serum iron" or "serum ferritin" or "transferrin" or "iron deficiency anemia" and "hot convulsion" ; the English search terms were anemia, iron-deficiency and seizures, febrile or pyrexial seizure or pyrexial convulsion. The literature was screened and extracted by two investigators according to the inclusion and exclusion criteria. The Newcastle-Ottawa Scale (NOS) was used for literature quality assessment. Stata SE 12.0 software was used for meta-analysis of whether iron deficiency anemia was a risk factor for children with febrile seizures, calculation of odds ratio (OR), and subgroup analysis based on different diagnostic criteria for iron deficiency anemia. ResultsA total of 89 relevant literatures were detected in this study. After screening, 26 articles that met the inclusion and exclusion criteria were finally included for meta-analysis. The results of the analysis showed that febrile seizures were associated with iron deficiency anemia [OR=2.24, 95% CI (1.758, 2.854), P<0.05]. ConclusionIron deficiency anemia is one of the risk factors for febrile seizures in infants and preschool children.