早期胃癌病人血清CypB改变及其辅助诊断价值

目的探讨血清亲环素B（CypB）在早期胃癌病人中的改变及辅助诊断价值，以期为早期胃癌的临床诊疗提供参考。方法纳入49例早期胃癌病人为观察组。另纳入同期健康体检者45名作为对照组。采用酶联免疫吸附法检测2组外周血血清CypB、癌胚抗原（CEA）及糖类抗原-199（CA-199）水平，并分析各指标在早期胃癌病人中的诊断价值，以及早期胃癌病人外周血CypB水平与CEA及CA-199的相关性。结果观察组病人外周血血清CypB、CEA及CA-199水平均明显高于对照组（P < 0.01）；观察组病人外周血血清CypB水平与CEA及CA-199均呈明显正相关关系（P < 0.05）；ROC曲线分析显示，以4.030 ng/mL为截点值，CypB诊断早期胃癌的敏感性为76.36%，特异性为75.51%，曲线下面积为0.766，诊断效能优于CEA及CA-199。结论早期胃癌病人外周血血清CypB水平升高，对辅助诊断具有一定价值。

Change of the serum level of cyclophilin B and its diagnostic value in patients with early gastric cancer

ObjectiveTo investigate the changes of the serum level of cyclophilin B(CypB) and its auxiliary diagnosis value in patients with early gastric cancer, and provide reference in the clinical diagnosis and treatment of early gastric cancer.MethodsForty-nine patients with early gastric cancer and 45 health examiners were divided into the observation group and control group, respectively.The serum levels of CypB, carcinoembryonic antigen(CEA) and carbohydrate antigen-199(CA-199) in two groups were detected using enzyme linked immunosorbent assay.The early diagnostic value of each index in early gastric cancer patients was evaluated, and the correlation of serum level of CypB with CEA and CA-199 in patients with early gastric cancer was analyzed.ResultsThe difference of general data between two groups was not statistically significant(P>0.05).The serum levels of CypB, CEA and CA-199 in observation group were significantly higher than those in control group(P < 0.01).The serum level of CypB in observation group was significantly positively correlated with CEA and CA-199(P < 0.05).The ROC curve analysis showed that when 4.030 ng/mL was set as the cut-off point, the sensitivity and specificity of CypB in the diagnosis of early gastric cancer were 76.36% and 75.51%, respectively, the area under the curve was 0.766, and the diagnostic efficacy of CypB was better than that of CEA and CA-199.ConclusionsThe serum level of CypB in patients with early gastric cancer increases, which has certain value for auxiliary diagnosis.