| EGFR信号通路在骨性关节炎研究中进展 |
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| 作者姓名： | 曾文波 兰生辉 蔡贤华 刘曦明 |
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| 作者单位： | 1. 430070 武汉，中国人民解放军中部战区总医院骨科（湖北省骨创伤救治临床医学研究中心）；510515 广州，南方医科大学 |
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| 基金项目： | 国家自然科学基金资助项目(81601902); 湖北省自然科学基金(2015CFB240); 博士后科学基金(2015M572817); 湖北省自然科学基金专项(2017ACA099); 湖北省卫生和计划生育委员会联合基金项目(WJ2018H0064) |
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| 摘 要： | 软骨细胞在骨关节表面形成保护关节的软骨组织，关节软骨细胞的增殖、分化、凋亡及代谢的失衡将导致骨性关节炎（OA）的发生。近年研究发现，表皮生长因子受体（EGFR）信号通路是多功能细胞因子，与人体多种器官和组织的病理及生理过程紧密相关，在调节软骨细胞的生长及代谢过程中发挥重要作用。因此，本文围绕OA病变中EGFR信号通路在OA中的作用和机制进行综述，以期为OA和其他骨关节疾病的研究和治疗提供新的方法和思路。
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| 关 键 词： | 受体，表皮生长因子 骨性关节炎 软骨细胞 生物学作用 |
| 收稿时间： | 2018-10-12 |
Progress of the role of EGFR signaling pathway in osteoarthritis |
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| Authors: | Wenbo Zeng Shenghui Lan Xianhua Cai Ximing Liu |
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| Institution: | 1. Depatment of Othopedics, Central theater command General Hospital of the PLA (Clinical Medical Research Center for Bone Trauma Treatment in Hubei Province), Wuhan 430070, China; Southern Medical University, Guangzhou 510515, China |
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| Abstract: | Chondrocytes form articular cartilage on the surface of arthrosis. The proliferation, differentiation, apoptosis and metabolic imbalance of articular chondrocytes will lead to the occurrence of osteoarthritis (OA). Recent studies have shown that EGFR signaling pathway is a multifunctional cytokine, which is closely related to the pathological and physiological processes of various organs and tissues, and plays an important role in regulating the growth and metabolism of chondrocytes. Therefore, this review focuses on the role and mechanism of EGFR signaling pathway in OA, in order to provide new methods and ideas for the research and treatment of OA and other bone and joint diseases. |
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| Keywords: | Receptor epidermal growth factor Osteoarthritis Chondrocytes Biological functions |
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