青少年肌阵挛癫痫患者的大尺度脑网络研究

采用静息态功能性磁共振成像(rs-fMRI)数据探究青少年肌阵挛癫痫(JME)患者大尺度脑网络的变化。采集17例JME患者和15名正常志愿者的脑部静息态功能磁共振成像数据,两组均使用偏相关系数构建静息态脑网络。分别计算JME患者组与正常对照组的阈值,构建二值化脑网络。计算两组被试各个脑区的介数值,采用双样本t检验对比两组脑网络介数值的差异(Bonferroni 校正,P<0.01),找出介数值发生显著变化脑区。结果表明,偏相关系数构造的脑网络具有小世界属性。JME患者组脑网络中脑区的介数值相比正常对照组有显著性差异。与正常对照组相比,JME患者组介数值显著降低的脑区有2个,介数值显著升高的脑区有17个。其中属于默认模式网络(DMN)的脑区有8个,属于突显网络(SN)的脑区有5个。JME患者组介数值显著降低的脑区有右侧中央旁小叶和右侧后扣带回,介数值显著增高脑区主要是右侧背外侧额上回、左侧枕中回、右侧楔前叶和右侧舌回等。JME患者介数值发生显著改变的脑区主要属于默认模式网络和突显网络。可以推断出默认模式网络和突显网络内部脑区间连接发生改变,信息传递产生变化。由此可能会导致JME患者大脑功能发生改变,造成患者的认知能力与执行能力等功能受损。

The Large-Scale Brain Network Dysfunction of Juvenile Myoclonus Epilepsy Patients

Resting-state functional magnetic resonance imaging (fMRI) data were used to investigate the changes of large-scale brain networks in juvenile myoclonus epilepsy (JME) patients. The brain rs-fMRI data of 17 JME patients and 15 normal volunteers were collected. The partial correlation coefficient was used to construct resting state brain networks in both groups. Thresholds were independently calculated for the JME group and the normal control group. A binary brain network was built. The betweenness values of each brain region of the two groups were calculated. Two-sample T test was used to compare the differences in the betweenness values of brain network between the two groups (Bonferroni correction, P<0.01). The brain regions with significant changes of betweenness values were identified. The brain network was constructed by the partial correlation coefficient, and the brain network showed small-world property. The betweenness values of brain regions of JME patients group was significantly different from that of normal control group. Compared with the normal control group, in the JME patient group, there were 2 brain regions with significantly lower betweenness values and 17 brain regions with significantly higher betweenness values. Among them, 8 brain regions belong to the default mode network (DMN), and 5 brain regions belong to the salience network (SN). The betweenness values of the right paracentral lobule and the right posterior cingulate gyrus were significantly reduced in JME group. The regions of significantly increased betweenness values were mainly distributed in the right dorsolateral superior frontal gyrus, the left middle occipital gyrus, the right precuneus, the right lingual gyrus. The brain regions where the betweenness value of JME patients had significantly changed mainly belong to the default mode network and the salience network. It can be inferred that the connections between internal brain regions had changed in default mode network and salience network separately. These changes showed that JME patients' brain functions had been influenced and changed, resulting in impaired cognitive and executive functions.