预后营养指数与乳腺癌临床病理关系研究

目的研究预后营养指数（PNI）与乳腺癌的预后及临床病理之间的关系。方法回顾性分析2014年1月至2017年1月肿瘤外科收治的乳腺癌病人90例的临床资料与随访资料，分析PNI与其临床病理及术后并发症的关系。结果PNI评分较高的病人术后近期并发症发生率较低（P < 0.01）；PNI与乳腺癌的免疫组化指标Her-2、Ki-67均有关，PNI≥45组病人的Her-2和Ki-67阳性率均低于PNI < 45组（P < 0.05）；PNI≥45组病人肿瘤直径小于PNI < 45组（P < 0.01）；PNI≥45组乳腺癌局部复发率为3.33%，与PNI < 45组复发率13.3%差异无统计学意义（P > 0.05），PNI≥45组全身转移率为5%，低于PNI < 45组全身转移率20%（P < 0.05）。结论PNI是乳腺癌的一种预后预测指标，具有简单、易行的特点。

Study on the relationship between the prognosis nutritional index and clinicopathology of breast carcinoma

ObjectiveTo explore the relationship between prognosis nutritional index(PNI), prognosis and clinicopathology of breast cancer.MethodsThe clinical data and following-up data of breast cancer patients from January 2014 to January 2017 were retrospectively analyzed.The relationships between PNI, and pathology and postoperative complications were analyzed.ResultsThe incidence rate of postoperative complications in patients with high PNI score was lower(P < 0.01), and PNI was related to Her-2 and Ki-67.The positive rates of Her-2 and Ki-67 in patients with PNI more than or equal to 45 were less than those in patients with PNI less than 45(P < 0.05).The tumor size in patients with PNI more than or equal to 45 was less than that in patients with PNI less than 45(P < 0.01).The local recurrence rates of breast cancer in patients with PNI more than or equal to 45 and PNI less than 45 were 3.33% and 13.3%, respectively, and the difference of which was not statistically significant(P > 0.05), and the systemic metastasis rate in patients with PNI more than or equal to 45(5%) was lower than that in patients with PNI less than 45(20%)(P < 0.05).ConclusionsPNI is a prognostic index of breast cancer, which is simple and easy to perform.