肿瘤标志物和炎性指标物联合检测对非小细胞肺癌的诊断价值

目的探讨血清肿瘤标志物癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）和炎性标志物白细胞（WBC）、血小板（PLT）、中性粒细胞（NE）、淋巴细胞（LY）、血小板与淋巴细胞比值（PLR）、中性粒细胞/淋巴细胞比值（NLR）检测在非小细胞肺癌（NSCLC）诊断中的应用价值。方法选取NSCLC病人147例（NSCLC组），收集同期健康体检者84名资料作为对照组。测定2组WBC、PLT、NE、LY、CEA、CYFRA21-1水平，并计算PLR和NLR，比较2组各指标水平或阳性率差异，以及联合检测对NSCLC的诊断效率。结果NSCLC组病人WBC、PLT、NE、NLR、PLR、CEA、CYFRA21-1均明显高于对照组（P < 0.01），LY明显低于对照组（P < 0.01）。Ⅲ+Ⅳ期NSCLC病人WBC、NE、CYFRA21-1水平均高于Ⅰ+Ⅱ期（P < 0.05）。鳞癌病人CEA水平低于腺癌（P < 0.05），CYFRA21-1水平高于腺癌（P < 0.05）。CEA、CYFRA21-1、PLR、NLR联合检测诊断NSCLC的敏感性较单项检测敏感性明显增高，其对NSCLC诊断效率为0.926，4项联合检测诊断早期NSCLC的诊断效率为0.881。结论WBC、PLT、NE、LY、CEA、CYFRA21-1、PLR和NLR水平对于NSCLC有一定的诊断价值，血液WBC、PLT、NE、LY、CEA、CYFRA21-1、PLR和NLR水平联合检测对于NSCLC的诊断较单一指标具有更高的诊断价值。

Diagnostic value of combined detection of tumor markers and inflammatory markers in non-small cell lung cancer

ObjectiveTo investigate the detection of serum tumor markers carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and inflammatory markers white blood cell (WBC), platelet (PLT), neutrophil (NE), lymphocyte (LY), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of non-small cell lung cancer (NSCLC).MethodsA total of 147 NSCLC patients (NSCLC group), and 84 healthy people who had physical examination in the same period (control group) were selected.The levels of WBC, PLT, NE, LY, CEA and CYFRA21-1 were measured in two groups, and PLR, NLR were calculated.The differences of the levels or positive rates of the indicators in two groups were compared, and diagnostic efficacy of combined detection in NSCLC was analyzed.ResultsThe levels of WBC, PLT, NE, NLR, PLR, CEA and CYFRA21-1 in NSCLC group were significantly higher than those in control group, and the LY level was obviously lower than that in control group(P < 0.01).The levels of WBC, NE and CYFRA21-1 of NSCLC patients in stage Ⅲ+Ⅳ were higher than those in stage Ⅰ+Ⅱ(P < 0.05).The level of CEA and CYFRA21-1 in patients with squamous cell carcinoma was lower and higher than that in patients with adenocarcinoma (P < 0.05), respectively.The sensitivity of combined detection of CEA, CYFRA21-1, PLR and NLR in the diagnosis of NSCLC was significantly higher than that of single detection.The diagnostic efficiency of combined detection in NSCLC and early NSCLC was 0.926 and 0.881, respectively.ConclusionsThe levels of WBC, PLT, NE, LY, CEA, CYFRA21-1, PLR and NLR have certain diagnostic values for NSCLC, and the combined detection of WBC, PLT, NE, LY, CEA, CYFRA21-1, PLR and NLR has higher diagnostic value for NSCLC than a single indicator.