曲安奈德联合透明质酸钠治疗膝关节骨性关节炎的Meta分析

目的系统评价使用曲安奈德联合透明质酸钠治疗膝关节骨性关节炎的有效性。 方法依据Meta分析要求，对CBM、CNKI、PubMed、Springer、Embase、万方、维普、Cochrane Library、中国科技论文统计与分析网、专利数据库等进行检索，严格评价纳入以曲安奈德联合透明质酸钠作为主要干预措施，治疗膝关节骨性关节炎的研究文献质量，并收录相关有效的数据资料，检索年限从建库至2019年03月运用Review Manager5.3、Stata/MP 15.1对总有效率和Lysholm膝关节评分进行Meta分析。 结果最终纳入18篇文献，受试者共1576人，16篇文献报道了总有效率，5篇报道了Lysholm膝关节评分。对于膝关节骨性关节炎的治疗，曲安奈德联合透明质酸钠的总有效率（95% CI：2.79~5.25，P<0.01）高于透明质酸钠；Lysholm膝关节评分（95% CI：0.84~1.65，P<0.01）优于透明质酸钠，差异均有统计学意义。 结论在治疗膝关节骨性关节炎时，曲安奈德联合透明质酸钠具有更高的总有效率，治疗后的膝关节功能评分要优于单独使用透明质酸钠。

The Effect of Triamcinolone Acetonide Combined with Sodium Hyaluronanin the Treatment of Knee Osteoarthritis: A Meta-Analysis

ObjectiveTo systematically evaluate the efficacy of triamcinolone acetonide combined with sodium hyaluronan in the treatment of knee osteoarthritis. MethodsAccording to Meta-analysis requirements, The Literature researchwas published both at demestic and abroad from database founded to March 2019. The retrieval was performed in CBM, CNKI, PubMed, Springer, Embase databases, Wanfang, Weipu, Cochrane Library, etc. The total effective rate and Lysholm knee joint score was systematicallyevaluated by using the software named Review Manager 5.3, Stata/MP15.1 and R-language. ResultsA total of 1,576 patients in 18 included studies were enrolled in the meta- analysis. Reference reports were finally included and a total of 1,576 subjects were enrolled. The total effective rate was shown in 16 included studies, 5 included studies showed Lysholm knee joint score. The total effective rate of triamcinolone acetonide combined with sodium hyaluronanin was higher than that of the sodium hyaluronanin (95% CI: 2.79-5.25, P<0.01), Lysholm knee joint score of triamcinolone acetonide combined with sodium hyaluronanin was superior to that of the sodium hyaluronanin (95% CI: 0.84-1.65, P<0.01), the difference was considered statistically significant. ConclusionsIn the treatment of knee osteoarthtitis, triamcinolone acetonide combined with sodium hyaluronanhashiger total effective rate and Lysholm knee joint score than sodium hyaluronan.