脑胎盘率对预测胎儿生长受限的作用

目的探讨脑胎盘率(cerebroplacental ratio，CPR)预测胎儿生长受限(fetal growth restriction，FGR)的作用。 方法对2015年1月至2017年12月在广州医科大学附属第二医院收治的52例FGR孕妇和同期正常产前检查分娩的49例孕妇临床资料进行回顾性分析。通过ROC曲线分析脑胎盘率、脐动脉、大脑中动脉血流对FGR不良妊娠结局预测，并计算曲线下面积(area under curve，AUC)，对比各血流指标诊断FGR的灵敏度、特异度。 结果孕28～31^＋6周及孕32～36^＋6周CPR指标较脐动脉及大脑中动脉血流指标更具有优越性，孕28～31^＋6周及孕32～36^＋6周曲线下面积值为0.82和0.96，截断值为1.74和1.59，灵敏度为96%和90%，特异度为79%和97%。 结论CPR可作为一项预测FGR的指标，具有临床意义。

The role of cerebroplacental ratio in predicting fetal growth restriction

ObjectiveTo explore the role of cerebroplactic ratio (CPR) in predicting fetal growth restriction (FGR). MethodsThe clinical data of 52 pregnant women with FGR and 49 normal pregnant women, who were admitted to the Second Affiliated Hospital of Guangzhou Medical University from January 2015 to December 2017, were retrospectively analyzed. ROC curve was used to analyze the prediction of adverse pregnancy outcome of FGR by cerebral placenta rate, umbilical artery flow and middle cerebral artery blood flow. And the sensitivity and specificity of FGR diagnosed were analyzed by calculating area under curve (AUC) and comparing each blood flow index. ResultsThe CPR at 28-31^{+ 6} weeks of gestation and 32-36^{+ 6} weeks of gestation were superior to those of umbilical artery and middle cerebral artery blood flow. AUC values at 28-31^{+ 6} weeks of gestation and 32-36^{+ 6} weeks of gestation were 0.82 and 0.96, with cutoff values of 1.74 and 1.59. Their sensitivity was 96% and 90%, and the specificity is 79% and 97%, respectively. ConclusionCPR was clinically useful as a predictor of FGR.