奥氮平对伴或不伴代谢综合征的精神分裂症病人认知功能的差异性影响分析

目的研究分析奥氮平对伴或不伴代谢综合征的精神分裂症病人在认知功能上的差异以及影响因素。方法选取2014年3月至2017年3月长期服用奥氮平伴有代谢综合征的精神分裂症病人50例（观察组）和不伴有代谢综合征的精神分裂症病人50例（对照组）作为研究对象，应用重复性神经心理状态测验（RBANS）对2组的认知功能进行评估和观察。结果2组在药物使用时间和剂量上差异有统计学意义（P < 0.01）；观察组PANSS总分和阴性症状分高于对照组（P < 0.05），在阳性症状分和一般病理分上差异无统计学意义（P>0.05）。观察组的空腹血糖、收缩压、舒张压水平高于对照组（P < 0.05~P < 0.01），且高密度脂蛋白水平明显低于对照组（P < 0.01），观察组即刻记忆、注意、延时记忆3个因子评分和总分均低于对照组（P < 0.05），2组病人三酰甘油水平、视觉广度和言语功能因子评分差异无统计学意义（P>0.05）。结论和不伴有代谢综合征的精神分裂症病人相比，伴有代谢综合征的精神分裂症病人认知功能更差，血糖的升高可能参与了认知功能缺损的发生机制。

Effect of olanzapine on the cognitive function of schizophrenic patients complicated with or without metabolic syndrome

ObjectiveTo investigate the effects of olanzapine on the cognitive function of schizophrenic patients complicated with or without metabolic syndrome, and its influencing factors.MethodsFifty schizophrenic patients complicated with metabolic syndrome and 50 schizophrenic patients without metabolic syndrome from March 2014 to March 2017 were divided into the observation group and control group, respectively.The cognitive functions in two groups were observed and assessed using RBANS.ResultsThere was statistical significance in the time and dose of drug use between two groups(P < 0.01), the total score of PANSS and negative symptom score in observation group were significantly higher than those in control group(P < 0.05), and there was no statistical significance in the positive symptom score and general pathological score(P>0.05).The levels of GLU, SBP and DBP in observation group were significantly higher than those in control group(P < 0.05 to P < 0.01), and the level of HDL in observation group was significantly lower than that in control group(P < 0.01).The scores of immediate memory, attention and delayed memory, and its total score in observation group were significantly lower than those in control group(P < 0.05).There was no statistical significance in the scores of the level of TG, visual breadth and speech function between two groups(P>0.05).ConclusionsCompared with schizophrenic patients complicated without metabolic syndrome, the cognitive function of schizophrenic patients complicated with metabolic syndrome is worse, and the increasing of blood glucose level may be involved in the mechanism of cognitive impairment.