血清白细胞介素-17与视神经脊髓炎谱系疾病的关系

目的研究视神经脊髓炎谱系疾病（NMOSD）血清中白细胞介素17（IL-17）在发病中的意义及其与疾病严重程度的相关性。方法酶联免疫吸附法检测36例NMOSD急性期病人（NMOSD组）与30名健康志愿者（HCs组）血清IL-17；对NMOSD组血清IL-17水平与扩展残疾状况评分（EDSS）、脊髓受累节段数、病灶是否增强及水通道蛋白4抗体（AQP4-Ab）滴度等临床指标的相关性进行分析。结果NMOSD组血清IL-17水平为（35.54±10.71），较HCs组（HCs）（27.03±7.09）明显升高（P＜0.001）。NMOSD组血清IL-17水平与EDSS评分、脊髓受累节段数呈正相关（P＜0.01），病灶有强化者血清IL-17水平较病灶无强化者明显升高（P＜0.01），AQP4-Ab对血清IL-17水平无影响（P>0.05）。多元回归分析显示血清IL-17水平与EDSS评分、脊髓受累节段数存在正相关性（P＜0.01和P＜0.05）。结论IL-17可能参与了NMOSD的发病过程，与疾病严重程度相关，可以作为病情判断及疾病潜在进展的预测指标之一。

Study on the relationship between the serum level of interleukin-17 and neuromyelitis spectrum diseases

ObjectiveTo investigate the significance of serum the level of interleukin-17(IL-17) in the neuromyelitis optica Spectrum disorders(NMOSD), and its correlation with disease severity.MethodsThe serum concentrations of IL-17 in 36 patients with NMOSD(NMOSD group) and 30 healthy volunteers(HCs group) were measured using enzyme-linked immunosorbent assay(ELISA).The correlations between serum level of IL-17 and extended disability score(EDSS), number of spinal cord involved segments, enhancement of lesion and titer of aquaphosin 4 antibody(AQP4-Ab) were analyzed in NMOSD group.ResultsThe serum level of IL-17 in NMOSD group(35.54±10.71) was significantly higher than in HCs group(27.03±7.09)(P < 0.01).The serum level of IL-17 in NMOSD group was positive correlation with EDSS score and number of spinal cord involved segments(P < 0.01), the serum level of IL-17 in patients with enhancement of lesion significantly increased compared with patients without enhancement of lesion(P < 0.01), and there was not significant correlation between IL-17 level and antibody titers of AQP4-Ab(P>0.05).The results of multivariate regression analysis showed that the serum level of IL-17 were positively correlated with EDSS score and number of spinal cord lesion(P < 0.01 and P < 0.05).ConclusionsThe IL-17 may participate in the pathogenic process of NMOSD, and can be used as one of the predictors in judging disease and potential progression of disease.