| B7-H3在胶质瘤免疫研究中的新进展 |
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| 引用本文： | 赵嘉银,范益民. B7-H3在胶质瘤免疫研究中的新进展[J]. 中华神经创伤外科电子杂志, 2019, 5(1): 56-59. DOI: 10.3877/cma.j.issn.2095-9141.2019.01.012 |
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| 作者姓名： | 赵嘉银 范益民 |
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| 作者单位： | 1. 030000 太原,山西医科大学第一附属医院神经外科 |
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| 摘 要： | B7-H3作为B7-CD28检查点通路的新成员,在肿瘤免疫过程中起到了极其重要的作用。大量研究表明,B7-H3在多数肿瘤中呈高表达,并与肿瘤的免疫逃逸相关联,且与肿瘤的黏连、侵袭和转移存在密不可分的关系。尽管B7-H3相关受体尚未明确,但是,针对其相关的8H9抗体已在临床上得到了初步性的成功。本文现围绕抗B7-H3在胶质瘤免疫研究中的最新进展综述如下。
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| 关 键 词： | B7-H3 胶质瘤 免疫治疗 |
| 收稿时间： | 2018-09-04 |
New progress of B7-H3 in glioma immunity |
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| Jiayin Zhao,Yimin Fan. New progress of B7-H3 in glioma immunity[J]. Chinese Journal of Neurotraumatic Surgery (Electronic Edition), 2019, 5(1): 56-59. DOI: 10.3877/cma.j.issn.2095-9141.2019.01.012 |
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| Authors: | Jiayin Zhao Yimin Fan |
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| Affiliation: | 1. Department of Neurosurgery, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030000, China |
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| Abstract: | As a new member of B7-CD28 checkpoint pathway, B7-H3 plays an important role in tumor immunity. A large number of studies have shown that B7-H3 is highly expressed in most tumors and is associated with tumor immune escape. At the same time, it is also closely related to adhesion, invasion and metastasis of tumor. Athough B7-H3 related receptors have not been identified, the 8H9 antibodies against B7-H3 have been clinically successful. In this paper, the latest progress in the study of glioma immunity against B7-H3 is discussed. |
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| Keywords: | B7-H3 Glioma Immunotherapy |
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