肺炎支原体肺炎患儿外周血CD64及心肌酶与血清MP-IgM抗体滴度的相关性

目的:探讨肺炎支原体肺炎（MPP）患儿外周血CD64、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）水平与血清MP-IgM抗体滴度的相关性。方法:选取天津市滨海新区塘沽妇产医院儿科收治的130例MPP确诊患儿，按照病情程度分为轻症组（76例）和重症组（54例）。采集患儿外周血测定血清CD64、CK、CK-MB、LDH及MP-IgM抗体滴度。分析不同病情程度患儿的各指标测定结果，分析不同MP-IgM抗体滴度患儿的CD64、CK、CK-MB、LDH水平，并分析CD64、CK、CK-MB、LDH与MP-IgM抗体滴度的相关性。结果:与轻症组相比，重症组患儿的血清CD64指数、CK、CK-MB、LDH水平明显更高（t=13.123、-3.780、-5.807、-7.576，均P<0.05）。重症组中MP-IgM抗体高滴度者占比高于轻症组，低滴度者占比低于轻症组（χ2=58.197，P<0.05）。不同血清MP-IgM抗体滴度患儿的CD64指数、CK、CK-MB、LDH水平比较，均有高滴度组＞中滴度组＞低滴度组，3组对比差异均有统计学意义（F=8.326、11.744、19.568、35.474，均P<0.05）。相关性分析显示，MPP患儿病情轻重与MP-IgM抗体滴度呈正相关（r=0.556，P=0.000）。CD64指数、CK、CK-MB、LDH均与MP-IgM抗体滴度呈正相关（r=0.521、0.391、0.485、0.598，均P＜0.05）。结论:CD64、CK、CK-MB及LDH均与MP-IgM抗体滴度呈正相关，监测4项指标变化对于预测MPP患儿病情变化，指导治疗方案调整有积极作用。

Correlation between peripheral blood CD64, myocardial enzyme and serum MP-IgM antibody titer in children with Mycoplasma pneumoniae pneumonia

Objective: To investigate the correlation between the levels of peripheral blood CD64，creatine kinase（CK），creatine kinase isoenzyme（CK-MB），lactate dehydrogenase（LDH） and serum MP-IgM antibody titer in children with Mycoplasma pneumoniae pneumonia （MPP）. Methods: A total of 130 children with MPP diagnosed in pediatrics of Tanggu Maternity Hospital in Tianjin Binhai New Area were selected and divided into mild group（76 cases） and severe group（54 cases）.The peripheral blood of children was collected and the antibody titers of serum CD64，CK，CK-MB，LDH and MP-IgM were measured. The measurement results of various indexes in children with different disease degrees were analyzed，the levels of CD64，CK，CK-MB and LDH in children with different MP-IgM antibody titers were measured，and the correlation between CD64，CK，CK-MB，LDH and MP-IgM antibody titers were analyzed. Results: Compared with the mild group，the levels of serum CD64 index，CK，CK-MB and LDH in the severe group were significantly higher（t=13.123，-3.780，-5.807，-7.576，all P<0.05）.The proportion of MP-IgM antibody with high titer in severe group was higher than that in mild group，and the proportion of MP-IgM antibody with low titer was lower than that in mild group（χ2=58.197，P<0.05）.The levels of CD64 index，CK，CK-MB and LDH in children with different serum MP-IgM antibody titers were higher in high titer group than in medium titer group and lower titer group. The differences among the three groups were statistically significant（F=8.326，11.744，19.568，35.474，all P<0.05）.Correlation analysis showed that the severity of MPP was positively correlated with MP-IgM antibody titer（r=0.556，P=0.000）.CD64 index，CK，CK-MB and LDH were positively correlated with MP-IgM antibody titer（r=0.521，0.391，0.485，0.598，all P<0.05）. Conclusion: There is a positive correlation between peripheral blood CD64，CK，CK-MB and LDH and serum MP-IgM antibody titer. Monitoring the changes of four indexes plays a positive role in predicting the changes of MPP children's condition and guiding the adjustment of treatment plan.