新基因丙型肝炎病毒核心蛋白结合蛋白6（HCBP6）的发现和研究

丙型肝炎病毒核心蛋白结合蛋白6（HCBP6）是成军教授课题组利用酵母双杂交技术首先发现的与丙型肝炎病毒核心蛋白结合的蛋白。课题组进一步发现HCBP6可以感受肝细胞内总胆固醇与甘油三酯水平变化并调节总胆固醇与甘油三酯水平。动物模型发现,HCBP6基因敲除小鼠在高脂饮食喂养下会出现糖脂代谢紊乱。课题组进一步发现韩国红参组分可通过调节HCBP6改善糖脂代谢,推动了含有该组分PTIB001治疗非酒精性脂肪性肝病的功能食品的问世。这些工作为基于PTIB001治疗NAFLD药物的研发提供了理论依据。

Discovery and study of hepatitis C virus core protein binding protein 6 (HCBP6)

Hepatitis C virus (HCV) core protein binding protein 6 (HCBP6) is first identified by Professor Cheng Jun’s team as a protein binding to HCV core protein with the yeast two hybrid system. Professor Cheng’s team further found that HCBP6 can sensor the fluctuation of total cholesterol and triglyceride and help to maintain the homeostasis of lipid metabolism and glycometabolism. Homozygous HCBP6 knock-out mouse showed abnormal lipid metabolism and glycometabolism on high fat diet feeding. Professor Cheng’s team found that PTIB001 from Korean red ginseng might help to maintain homeostasis of lipid metabolism and glycometabolism through HCBP6 pathway. Professor Cheng’s team enhanced the development of functional food which contain PTIB001 for nonalcoholic fatty liver disease (NAFLD). These work provide theoretical evidence for the development of PTIB001 related agents for NAFLD.