κ阿片受体在抑郁中的作用及机制研究进展

抑郁症是一种严重的精神障碍疾病，发病率高，社会危害大。目前单胺重摄取抑制剂是临床治疗抑郁症的一线药物，但是普遍存在起效延迟，副作用多，并且治愈率低的问题。以阿片受体为靶点的抗抑郁药物研发显示出非常有希望的前景，临床研究发现，κ阿片受体拮抗剂丁丙诺啡在难治型抑郁症中发挥良好的治疗效果。该文将对κ阿片受体在抑郁发生发展过程中的作用及其机制进行综述，总结强啡肽 /κ阿片受体在不同脑区中的作用。并介绍强啡肽 /κ阿片受体系统和促肾上腺皮质激素释放因子（corticotrophin releasing factor，CRF）系统是如何发挥相互作用调控行为，就参与介导抑郁样行为的κ阿片受体上游和下游分子的研究现状予以介绍，以期为将来的研究提供参考。

Research Progress of the Role and Underlying Mechanism of Dynorphin/κ Opioid Receptor in the Development of Depression

Depression is a serious mental disorder charactered by high prevalence，major depression always result in great harm to society. At present，the most popular antidepressants including monoamine reuptake inhibitors have some deficits including slower effect，side-effect. At the same time，some patients do not response adequately to the antidepressant medication.The development of drugs targeting opioid receptor has shown promising prospect，clinical studies have demonstrated that κ opioid receptor antagonist Buprenorphine could possibly cure depressive symptoms in patients with classical antidepressants treatment-resistant depression. In present review，we discuss the recent progress of the role of κ opioid receptor in different brain regions during the development of depression，and introduce the association between dynorphin/κ opioid receptor and CRF as well as monoamine system. Furthermore，we briefly introduce the upstream and downstream molecules of κ opioid receptor that contribute to the development of depression.