基于圆形分布法的广东省唇腭裂患儿受孕月份分析

目的探讨广东省唇腭裂患儿受孕月份的分布规律。 方法以2016—2017年在广东省范围内有产科资质的医疗机构内分娩的围产儿（孕28周至出生后7 d）及产妇为研究对象，将唇腭裂患儿受孕统计年度看成1个圆周，用圆形分布法对其中的先天性唇腭裂患儿的受孕时间进行聚集性分析。 结果2016—2017年广东省共监测围产儿3 748 435例，检出唇腭裂患儿5591例，其中男性患儿3137例、女性患儿2309例、性别不明或两性畸形患儿145例，排除性别不明患儿共包括唇裂1368例、腭裂913例、唇裂合并腭裂3165例。唇腭裂患儿的受孕高峰有时间聚集性（平均角 = 67.33，P<0.001），唇腭裂患儿的受孕高峰在3月上旬。其中单纯唇裂和唇裂合并腭裂的受孕高峰时间分别是2月下旬和3月中旬，为春季；单纯腭裂的受孕高峰时间差异无统计学意义。女性唇腭裂患儿的受孕时间存在高峰，为3月份，男性患儿的受孕时间差异无统计学意义。 结论广东省唇腭裂患儿的受孕高峰有时间聚集性，单纯唇裂和唇裂合并腭裂与单纯腭裂可能有不同病因构成，女性患儿的发病更受到季节性影响，春季应加强预防唇腭裂危险因素的暴露。

Circular distribution-based analyses of conception month of oral clefts cases of Guangdong Province

ObjectiveTo investigate the distribution of the conception month in oral clefts cases of Guangdong Province. MethodsThe statistical year of oral clefts cases conception date is regarded as a circle. The conception month clustering of oral clefts cases from the Birth Defects Monitoring Network of Guangdong Province during 2016-2017 by circular distribution method were analyzed. ResultsFrom 2016 to 2017, a total of 3, 748, 435 perinatal infants were monitored in Guangdong Province, 5591 cases with cleft lip or palate were detected, including 3137 male infants, 2309 female infants, 145 infants with unidentified gender. Excluding unidentified gender cases, 1368 cases with cleft lip, 913 cases with cleft palate, 3165 cases of cleft lip with palate. Oral clefts cases are conceived with a time aggregation (α = 67.33, P<0.001) , which is in the Early March. The time aggregation of cleft lip and cleft lip with cleft palate conception was in late February and mid-March, respectively. The time aggregation of cleft palate (CP) has no statistical significance. The conception time of female cleft cases have statistical significance of time aggregation, male cleft cases have no conception time aggregation. ConclusionsThe conception month of oral clefts cases in Guangdong Province has time aggregation. Cleft palate may have a different etiology model with cleft lip and cleft lip with cleft palate. The incidences of female cleft fetuses lip are more susceptible to conception time. Conception in spring should be alert to the occurrence of oral clefts.