围产儿先天性外部畸形的1：2配比病例对照研究

目的：探讨先天性外部畸形发病的危险因素,方法：对宝安区各级医疗机构监测的52例先天性外部畸形病例进行1：2配比病例对照研究。结果：单因素和多因素条件logistic回归分析表明：宝安区先天性外部畸形的主要危险因素是：是否足月产（多因素条件logistic回归分析偏回归系数＝1．4171,标准误＝0．4601,OR＝4．115）,孕早期不良精神刺激（偏回归系数＝2．1870,标准误＝0．7873,OR＝8．909）,孕早期用药（偏回归系数＝1．9178,标准误＝0．8072,OR＝6．808）,孕早期接触有害化学因素（偏回归系数＝0．9602,标准误＝0．4262,OR＝2．612）。结论：先天性外部畸形是多因素性疾病,环境及精神因素与其发病有明显联系。

A 1:2 matched case-control study on congenital external malformation during perinatal period

OBJECTIVE: To investigate the risk factors for congenital external malformation. METHODS: A 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000. RESULTS: Simple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612). CONCLUSIONS: Congenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.