The effect of carbamate local anesthetics on artificial lipid membrane |
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| Authors: | E Racanská P Svec V Racansky |
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| Affiliation: | Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, CSFR. |
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| Abstract: | The influence of phenylcarbamic acid basic esters with local anesthetic activity on the phase transition temperature (Tc) of a model dipalmitoylphosphatidylcholine (DPPC) membrane from gel to liquid crystalline state was studied. It was found that (Tc) in the presence of carbamate anesthetics decreases. The decrease of Tc (delta Tc) correlated well with the biological activity of the compounds studied. |
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