Characterization of isoquinoline alkaloids from Neolitsea sericea var. aurata by HPLC-SPE-NMR |
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| Authors: | Lee Shoei-Sheng Lai Yi-Chun Chen Chien-Kuang Tseng Li-Hong Wang Chen-Yu |
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| Affiliation: | School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China, and Bruker Biospin GmbH, Silberstreifen, D-76287 Rheinstetten, Germany. shoeilee@ha.mc.ntu.edu.tw |
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| Abstract: | Application of the HPLC-SPE-NMR technique to identify the alkaloids in an EtOH extract of the leaves of Neolitsea sericea var. aurata led to the characterization of 14 alkaloids while consuming plant material equivalent to 1.1 g. Of these, seven are N-oxides, four of which are new, namely, 9S,17S-pallidine Nalpha-oxide (6), 1S,2S-reticuline Nalpha-oxide (8), 6R,6aS-boldine Nbeta-oxide (9), and 6S,6aS-N-methyllaurotetanine Nalpha-oxide (13). Their structures were also confirmed by partial synthesis. |
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