| 盐酸左西替利嗪口腔崩解片的含量及有关物质测定 |
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| 引用本文： | 张理星,孙建合,朱啸风,崔志红.盐酸左西替利嗪口腔崩解片的含量及有关物质测定[J].中国药业,2008,17(12):47-48. |
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| 作者姓名： | 张理星 孙建合 朱啸风 崔志红 |
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| 作者单位： | 鲁南制药集团股份有限公司,山东临沂276006 |
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| 摘 要： | 目的建立测定盐酸左西替利嗪口腔崩解片含量及有关物质的方法。方法色谱柱为Alltima C18柱（250mm×4．6mm，5μm），流动相为甲醇-0．02mol／L磷酸二氢钾溶液（70：30），检测波长230nm，流速1．0mL／min。结果盐酸左西替利嗪质量浓度在0．08-0．12g／L内与峰面积线性关系良好（r=0．9992），平均回收率为99．8％，RSD=0．56％（n=9）。结论该法操作简便、灵敏度高、重现性好，结果准确可靠。
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| 关 键 词： | 高效液相色谱法 盐酸左西替利嗪 含量测定 有关物质 |
Determination of Levocetirizine Hydrochloride and Its Related Substances in Levocetirizine Hydrochloride Orally Disintegrating Tablets by HPLC |
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| Zhang Lixing,Sun Jianhe,Zhu Xiaofeng,Cui Zhihong.Determination of Levocetirizine Hydrochloride and Its Related Substances in Levocetirizine Hydrochloride Orally Disintegrating Tablets by HPLC[J].China Pharmaceuticals,2008,17(12):47-48. |
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| Authors: | Zhang Lixing Sun Jianhe Zhu Xiaofeng Cui Zhihong |
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| Institution: | ( Lunan Pharmaceutical Group Co., Ltd., Linyi, Shandong, China 276006) |
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| Abstract: | Objective To establish a HPLC method for determining the content and related substances of Levocetirizine Hydrochloride Orally Disintegrating Tablets. Methods Alltima C18 column（250 mm×4.6 mm,5μm） was used. The mobile phase consisted of methanol -0. 02 moL/L potassium phosphate monobasic solution（70：30）. The detection wavelength was at 230 nm. The flow rate was 1.0 mL/min. Results The standard curve of levocetirizine hydrochloride was linear in the range of 0.08-0. 12 g/L（r=0.999 2）.The average recovery rate was 99. 8% , RSD =0. 56% （ n =9）. Conclusion This method is simple, sensitive, reproducible and accurate. |
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| Keywords: | HPLC levocetirizine Hydrochloride quantitative determination related substances |
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