| 过继免疫治疗对手术后肺癌患者外周血免疫细胞表型影响的研究 |
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| 引用本文： | 卞隽,谭岩,方艳秋,姜艳芳,许淑芬,刘力华,段秀梅. 过继免疫治疗对手术后肺癌患者外周血免疫细胞表型影响的研究[J]. 中国妇幼保健, 2005, 20(22): 2979-2981 |
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| 作者姓名： | 卞隽 谭岩 方艳秋 姜艳芳 许淑芬 刘力华 段秀梅 |
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| 作者单位： | 1. 吉林省肿瘤医院,130012
2. 吉林大学第一医院中心实验室 |
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| 基金项目： | 吉林省科技厅重点项目（编号：20050402-3）;吉林省科技厅重点项目（编号：20040401-5）;吉林省科技厅国际合作项目（编号：20040707-2）;2004年长春市科技局计划项目（编号：2004218）;高等学校博士学科点专项科研基金（编号：20020183017） |
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| 摘 要： | 目的:探讨C IK过继免疫治疗对手术后肺癌患者免疫功能的影响。方法:采用流式细胞术检测40例肺癌患者外周血T细胞、B细胞和NK细胞表型。结果:肺癌患者CD3+、CD4+、CD4/CD8比值明显低于对照组并呈显著性差异,而CD8+细胞高于对照组(P<0.01)。经C IK治疗后CD3+、CD4+、CD3-/CD16+56+细胞和CD4/CD8比值都升高,其中CD4+、CD3-/CD16+56+细胞与治疗前比较呈显著性差异(P<0.05),而CD8+细胞与治疗前比较降低(P<0.05);CD19在治疗后稍有增高趋势,但无显著性差异。结论:C IK过继免疫治疗对肺癌患者免疫功能的恢复具有促进作用。
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| 关 键 词： | 过继免疫治疗 CIK 肺癌 免疫表型 |
| 文章编号： | 1001-4411（2005）22-2979-03 |
| 收稿时间： | 2004-12-11 |
| 修稿时间： | 2004-12-11 |
Effects of CIK on the Lymphocytes Immunophenotype in Patients with Lung Cancer |
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| BIAN Jun, TAN Yah, FANG Yah - Qiu, JIANG Yah - Fang, et al. Effects of CIK on the Lymphocytes Immunophenotype in Patients with Lung Cancer[J]. Maternal and Child Health Care of China, 2005, 20(22): 2979-2981 |
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| Authors: | BIAN Jun TAN Yah FANG Yah - Qiu JIANG Yah - Fang et al |
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| Affiliation: | 1 Department of Breast Surgery, Jilin Tumor Hospital, Changchun 130012, Jilin, China;2 Department of Central Laboratory, First Hospital, Jilin University, Changchun 130021, Jilin, China |
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| Abstract: | Objective:To investigate the immunophenotype of patients with lung cancer treated with CIK.Methods:The T cell and B cell subsets and NK cells in peripheral blood from patients with lung cancer(n=20)were detected with flow cytometry.Results:The CD3+、CD4+and CD4/CD8 from pre-operation patients with breast cancer were significantly lower than that of the control(P<(0.01)).Compared with the control group,the CD8+cells from patients with lung cancer were increased(P<(0.01)).The CD3+、CD4+、CD3-/CD16+56+cells and CD4/CD8 from post-operation patients treated with CIK were increased.Compared with pre-operation,the differences of CD4+、CD3-/CD16+56+cells were significant(P<0.05)and the CD8+cells were decreased((P<0.05).)Conclusion:The immunological function of patients with lung cancer is decreased and con be enhanced by CIK adoptive immunotherapy. |
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| Keywords: | Adoptive immunotherapy CIK Lung cancer Immunophenotype |
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