| 原发性高血压和动脉硬化性脑梗死及腔隙性脑梗死患者的HLA-DQA1遗传易感性 |
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| 引用本文： | 沈乃莹,金宇安,闫征,何培英.原发性高血压和动脉硬化性脑梗死及腔隙性脑梗死患者的HLA-DQA1遗传易感性[J].中华医学杂志,2001,81(6):352-355. |
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| 作者姓名： | 沈乃莹 金宇安 闫征 何培英 |
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| 作者单位： | 1. 北京中医药大学附属护国寺中医医院西医内科教研组,
2. 北京大学人民医院中心实验室 |
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| 基金项目： | 北京市西城区科委三项科研基金资助项目(20001250) |
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| 摘 要： | 目的 探讨原发性高血压(EH)、动脉粥样硬化性血栓性脑梗死(ABI)及腔隙性脑梗死(LS)患者HLA-DQA1位点的基因分型及其遗传易感性。方法 采用PCR-SSP方法对EH、ABI及LS共155例患者和正常对照64人进行HLA-DQA1位点的基因分型和遗传易感性分析。结果 EH、ABI及LS组的HLA-DQA1*0301基因频率均明显高于正常对照组，分别为33.6538对17.9688，36.5854对17.9688，33.0645对17.9688（P<0.01）,而HLA-DQA1*0103基因频率却明显低于正常对照组(P<0.05或P<0.01)。结论 HLA-DQA1*0301等位基因可能与EH、ABI及LS的遗传易感性相关,而HLA-DQA1*0103等位基因可能与其保护性相关。
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| 关 键 词： | 原发性高血压 动脉硬化性脑梗死 腔隙性脑梗死 遗传易感性 HLA－DQA1 |
| 修稿时间： | 2000年11月17 |
A study of the hereditary susceptibility of HLA-DQA1 to essential hypertension, athrothrombotic brain infarction and lacunar stroke |
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| SHEN Naiying ,YAN Zheng,HE Peiying et al.A study of the hereditary susceptibility of HLA-DQA1 to essential hypertension, athrothrombotic brain infarction and lacunar stroke[J].National Medical Journal of China,2001,81(6):352-355. |
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| Authors: | SHEN Naiying YAN Zheng HE Peiying |
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| Institution: | Department of Western Internal Medicine, Huguosii Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Traditional Chinese Medicine and Pharmacy, Beijing 100035, China. |
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| Abstract: | Objective To study the types of HLA DQA1 alleles in patients with essential hypertension (EH), athrothrombotic brain infarction (ABI) and lacunar stroke (LS) and normal control individuals and the hereditary susceptibility of HLA DQA1 alleles to those diseases. Methods The allelic typing of HLA DQA1 was detected by PCR SSP in 155 cases of EH, ABI and LS and 64 normal individuals. Results The frequencies of HLA DQA1*0301 in EH, ABI and LS groups were obviously higher than that in normal control group (33 6538 vs 17 9688, 36 5884 vs 17 9688, 33 0645 vs. 17 9688, P <0 01) .The frequencies of HLA DQA1*0103 in groups of EH, ABI, LS, ABI with EH, and LS with EH were lower than that in the normal control group (6 7308 vs17 1875, RR =0 3916 , P <0 01;6 0976 vs. 17 1875, RR =0 3548 , P <0 05;6 4566 vs17 1875, RR =0 3754 , P <0 01;2 3809 vs17 1875, RR =0 1385 , P <0 01;3 5714 vs. 17 1875, RR =0 2078 , P <0 01. Conclusion HLA DQA1*0301 allele may be a correlative gene with hereditary susceptibility of EH, ABI and LS, and HLA DQA1*0103 allele may be a protective gene of those diseases. |
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| Keywords: | Cerebral infarction HLA DQ A1 antigens Genetic predisposition to disease |
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