盐酸羟甲唑啉治疗玫瑰痤疮相关持久性面部红斑的临床疗效与安全性研究

目的 探讨盐酸羟甲唑啉治疗玫瑰痤疮相关持久性面部红斑的临床疗效与安全性。方法 选取2020年6月—2021年3月西南医科大学附属医院接诊的87例玫瑰痤疮相关持久性面部红斑患者作为研究对象，以电脑产生随机数的方法将其分为试验组44例和对照组43例。其中，对照组仅外涂0.1%他克莫司软膏治疗，试验组在对照组基础上联合盐酸羟甲唑啉治疗。比较两组患者治疗2个月后的疗效指数评分、临床疗效、皮肤功能指标及不良反应发生率。结果 两组患者治疗前后疗效指数评分的差值比较，试验组优于对照组（P <0.05）；试验组临床有效率高于对照组（P <0.05）；两组患者治疗前后面部红斑量、经皮水分流失量的差值比较，试验组均优于对照组（P <0.05）；两组不良反应发生率比较，差异无统计学意义（P <0.05）。结论 盐酸羟甲唑啉治疗玫瑰痤疮相关性持久性面部红斑患者，有助于进一步减少面部红斑量，改善患者面部红斑症状，临床疗效较好且未明显增加药物不良反应。

Clinical efficacy and safety of oxymetazoline hydrochloride in treatment of rosacea-related persistent facial erythema

Objective To explore the clinical efficacy and safety of oxymetazoline hydrochloride in the treatment of rosacea-related persistent facial erythema.Methods A total of 87 patients with rosacea-related persistent facial erythema received in our hospital from June 2020 to March 2021 were selected as the research objects, and they were divided into the experimental group and the control group by computer random number method, of which 43 cases were in the control group single external application of 0.1% tacrolimus ointment treatment, 44 cases in the test group were treated with oxymetazoline hydrochloride on the basis of the control group. The efficacy index scores, clinical efficacy, skin function indicators, and incidence of adverse reactions were compared between the two groups of patients after 2 months of treatment.Results The difference of curative effect index scores between the two groups before and after treatment was higher in the experimental group than in the control group (P < 0.05); the clinical effect of the test group was better than that of the control group (P < 0.05); the difference of erythema and transdermal water shunt loss before and after treatment in the experimental group was higher than that in the control group (P < 0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P < 0.05).Conclusion Oxymetazoline hydrochloride in the treatment of patients with rosacea-related persistent facial erythema can help to further reduce the amount of facial erythema and improve the patient''s facial erythema symptoms. The clinical effect is good and does not significantly increase the adverse drug reactions.