Lower limb muscle volume estimation from maximum cross-sectional area and muscle length in cerebral palsy and typically developing individuals |
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| Institution: | 1. One Small Step Gait Laboratory, Evelina London Children''s Hospital, Guy''s and St Thomas'' NHS Foundation Trust, Guy''s Hospital, London SE1 9RT, United Kingdom;2. School of Biomedical Engineering and Imaging Sciences, King''s College London, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas'' Hospital, London SE1 7EH, United Kingdom;1. Department of Kinesiology, University of Georgia, Athens, GA, USA;2. Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA;3. Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA;4. Department of Radiology, Michigan State University, East Lansing, MI, USA;5. Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USA;6. Department of Orthopedics, Nemours AI duPont Hospital for Children, Wilmington, DE, USA;1. CSIRO Health and Biosecurity, The Australian e-Health & Research Centre, Herston, QLD, Australia;2. School of Psychology, University of Adelaide, Adelaide, SA, Australia;3. Department of Radiology, The Royal Adelaide Hospital, Adelaide, SA, Australia;4. Department of Computing, Imperial College London, London, United Kingdom;5. Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, USA |
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| Abstract: | BackgroundDeficits in muscle volume may be a significant contributor to physical disability in young people with cerebral palsy. However, 3D measurements of muscle volume using MRI or 3D ultrasound may be difficult to make routinely in the clinic. We wished to establish whether accurate estimates of muscle volume could be made from a combination of anatomical cross-sectional area and length measurements in samples of typically developing young people and young people with bilateral cerebral palsy.MethodsLower limb MRI scans were obtained from the lower limbs of 21 individuals with cerebral palsy (14.7 ± 3 years, 17 male) and 23 typically developing individuals (16.8 ± 3.3 years, 16 male). The volume, length and anatomical cross-sectional area were estimated from six muscles of the left lower limb.FindingsAnalysis of Covariance demonstrated that the relationship between the length*cross-sectional area and volume was not significantly different depending on the subject group. Linear regression analysis demonstrated that the product of anatomical cross-sectional area and length bore a strong and significant relationship to the measured muscle volume (R2 values between 0.955 and 0.988) with low standard error of the estimates of 4.8 to 8.9%.InterpretationThis study demonstrates that muscle volume may be estimated accurately in typically developing individuals and individuals with cerebral palsy by a combination of anatomical cross-sectional area and muscle length. 2D ultrasound may be a convenient method of making these measurements routinely in the clinic. |
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