Numerical simulation of hemodynamics in membranous obstruction of the suprahepatic inferior vena cava based on a subject-specific Budd-Chiari syndrome model |
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| Institution: | 1. School of Information and Control Engineering, China University of Mining and Technology, Xuzhou 221116, China;2. School of Medical Imaging, Xuzhou Medical University, 84West Huai-hai Road, Xuzhou 221004, China;1. IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, IA 52242, USA;2. Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA;3. Department of Medicine, The University of Iowa, Iowa City, IA 52242, USA;4. Department of Radiology, The University of Iowa, Iowa City, IA 52242, USA;5. Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA;6. Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA;7. Currently at CH2M, 1100 NE Circle Blvd., Suite 300, Corvallis, OR 97330, USA;1. Academic Department of obstetrics and gynaecology, Imperial College London, Chelsea and Westminster Hospital, SW10 9NH, United Kingdom;2. Chelsea and Westminster Hospital, SW10 9NH, United Kingdom;3. The Lister Hospital, Chelsea Bridge Rd, London SW1W 8RH, United Kingdom;1. Auckland Bioengineering Institute, The University of Auckland, New Zealand;2. Department of surgery, The University of Auckland, New Zealand;1. Departamento de Educación Física y Deporte, Universidad de Valencia, Spain;2. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain;3. Obesity and Cardiovascular Risk Unit, Pediatric Department, Consorcio Hospital General Universitario, University of Valencia, Spain;4. Departamento de Educación Física y Deporte, Universidad de Sevilla, Spain;5. Departamento de Didáctica de la Expresión Musical, Plástica y Corporal, Universidad de Valencia, Valencia, Spain;1. Mayo Clinic, 200 First Street SW; RO_Gu_01_28BIOM; Rochester, MN 55905 United States;2. Cincinnati Children''s Hospital, 3333 Burnet Avenue MLC 10001 Cincinnati, OH 45229-3039, United States |
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| Abstract: | BackgroundThis study was performed to determine the hemodynamic changes of Budd-Chiari syndrome when the inferior vena vein membrane is developing.MethodsA patient-specific Budd-Chiari syndrome vascular model was reconstructed based on magnetic resonance images using Mimics software and different degrees (16%, 37%, and 54%) of idealized membrane were built based on the Budd-Chiari syndrome vascular model using Geomagic software. Three membrane obstruction Budd-Chiari syndrome vascular models were established successfully and fluent software was used to simulate hemodynamic parameters, including blood velocity and wall shear stress.FindingsThe simulation results showed that there is low velocity and a low wall shear stress region at the junction of the inferior vena cava and the branches of the hepatic veins, and swirl may occur in this area. As the membrane develops, the size of the low velocity and low wall shear stress regions enlarged and the wall shear stress was increased at the membrane region. There was a significant difference in the mean values of wall shear stress between the different obstruction membrane models (P < 0.05).InterpretationHemodynamic parameters play an important role in vascular disease and there may be a correlation between inferior vena cava wall shear force changes and the slow development process of the inferior vena cava membrane. |
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