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Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats |
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| Authors: | Lonneke M. Staals Hans D. de Boer Jan van Egmond Frank Hope Francien van de Pol Anton H. Bom Jacques J. Driessen Leo H. D. J. Booij |
| Affiliation: | (1) Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;(2) Department of Anesthesiology, Erasmus University Medical Centre, Sophia Children’s Hospital, Sb 3060, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands;(3) Department of Anesthesiology and Pain Medicine, Martini General Hospital, Groningen, The Netherlands;(4) Department of Pharmacology, Organon Newhouse, a part of Merck, Sharp and Dohme, ML1 5SH Lanarkshire, Scotland, UK |
| Abstract: | PurposeSugammadex is a selective relaxant binding agent designed to encapsulate the aminosteroidal neuromuscular blocking agent rocuronium, thereby reversing its effect. Both sugammadex and the sugammadex–rocuronium complex are eliminated by the kidneys. This study investigated the effect of sugammadex on recovery of rocuronium-induced neuromuscular block in cats with clamped renal pedicles, as a model for acute renal failure. |
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