Influence of Solvent Composition on the Miscibility and Physical Stability of Naproxen/PVP K 25 Solid Dispersions Prepared by Cosolvent Spray-Drying |
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| Authors: | Amrit Paudel Guy Van den Mooter |
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| Affiliation: | (1) Laboratorium voor Farmacotechnologie en Biofarmacie, K.U.Leuven, Leuven, Belgium;(2) Herestraat 49, bus 921, 3000 Leuven, Belgium; |
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| Abstract: | Purpose To investigate the influence of solvent properties on the phase behavior and physical stability of spray-dried solid dispersions containing naproxen and PVP K 25 prepared from binary cosolvent systems containing methanol, acetone and dichloromethane. |
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