可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体与巨噬细胞的免疫学功能

背景:巨噬细胞进行抗原吞噬、分泌细胞因子以及迁移,均需囊泡转运,而可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族在囊泡转运过程中发挥重要作用。目的:全面了解可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体在巨噬细胞免疫活动中的功能和作用机制。方法:以"snare proteins,macrophages,SNARE蛋白,巨噬细胞"为检索词检索PubMed、Embase和维普数据库(2011-11),语言限定为英文或中文。经阅读题目和摘要进行初筛,排除研究方向与本文无关、内容重复性研究。另补充必要的对理解其作用机制有帮助的文献。结果与结论:最终纳入27篇文献。可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族是保证囊泡物质定向运输和准确卸载的分子基础,在巨噬细胞抗原吞噬、细胞因子分泌、以及移行过程中发挥作用。以可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族为切入点对巨噬细胞免疫活动进行研究是一种合理的策略。

Effect of soluble N-ethylmaleimide-sensitive factor attachment protein receptor on the immunological function of macrophages

BACKGROUND:Macrophage performs the antigen phagocytosis,secretion of cytokines and migration through vesicle transport.Soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE) is a family of proteins which mediate the transportation of vesicles.OBJECTIVE:To thoroughly understand the effects of SNARE proteins on the immune activities of macrophage and the function.METHODS:An online search of PubMed,Embase and VIP databases(2011-11) was performed using Key words of "SNARE proteins,macrophages" for articles published in English or Chinese.The irrelevant or repetitive papers were eliminated by screening for the titles and abstracts.Some essential articles that were helpful for understanding its mechanism were supplemented.RESULTS AND CONCLUSION:A total of 27 articles were included.SNARE family is the molecular basis to ensure the direct transportation of vesicles and accurate unloading,and plays a role in antigen phagocytosis of macrophages,cytokine secretion and migration.It is a reasonable strategy for research the immune activity of macrophages with the starting point of SNARE family.