江苏省439例HIV/AIDS患者KIR3DS1基因的检测分析

目的了解KIR3DS1基因在HIV/AIDS患者中的分布情况,初步分析其与艾滋病的相关性。方法以江苏省疾病预防控制中心(CDC)确认的439例HIV/AIDS患者为研究对象,应用PCR-SSP方法进行KIR3DS1基因的检测。分类资料用频数和百分比进行统计描述,用χ2检验分析病例组与历史性对照组携带KIR3DS1基因的差异。使用非条件Logistic回归分析KIR3DS1基因与HIV/AIDS疾病进程的关联性。结果 439例研究对象KIR3DS1基因出现频率为34.4%,基因频率为0.19。HIV/AIDS患者与江苏历史性健康对照组间携带KIR3DS1基因之间的差异无统计学意义(P>0.05),但与美国健康白人间有统计学差异(P<0.01)。调整年龄、性别、感染途径等因素后,携带KIR3DS1基因对HIV进展到AIDS无明显影响(P=0.188)。结论我国汉族人群KIR3DS1基因与艾滋病的相关性有待进一步研究。

Distribution of KIR3DS1 gene among 439 HIV/AIDS patients in Jiangsu province

Objective To examine the expression of KIR3DS1 gene in HIV/AIDS patients in Jiangsu province and analysis its effect in the development of AIDS.Methods A total of 439 HIV-1/AIDS patients whose infection was diagnosed in Center for Diseases Control(CDC) of Jiangsu province were collected,and the distribution of KIR3DS1 was detected by PCR-SSP.The Chi-square test and Logistic regression analysis were used to analyze the association between KIR3DS1 and AIDS.Results The detectable rate of KIR3D31 was 34.4% and the allele frequency was 0.19.There was no statistically significance for the distribution of KIR3DS1 between the HIV/AIDS patients and the historical healthy controls in Jiangsu province(P>0.05).Comparing the distribution of KIR3DS1 between the HIV/AIDS patients in Jiangsu province and the white Americans,a statistically significant difference was found(P<0.01).There was no significant effect(P=0.188) for the KIR3DS1 carriers in the progression from HIV to AIDS in the condition of adjusted influence factors,e.g.,age,sex,infective way,etc.Conclusion Further research should be necessary to ascertain the correlation of KIR3DS1 and AIDS development.